UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 10-K
________________________

[ X ] Annual report pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934 for the Fiscal Year ended July
31, 1998
                               OR
[     ] Transition report pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934 for the transition period from
_______ to _______

Commission file number 0-20772
CYPROS PHARMACEUTICAL CORPORATION
(Exact name of registrant as specified in its charter)

California                              33-0476164
(State or other jurisdiction of         (I.R.S.Employer
incorporation or organization)           Identification No.)
         
2714 Loker Avenue West
Carlsbad, California                    92008
(Address of principal executive offices)(Zip Code)

Registrant's telephone number, including area code:
(760) 929-9500

Securities registered pursuant to Section 12(b) of the Act: None
Securities registered pursuant to Section 12(g) of the Act:
Common Stock, no par value
(Title of class)
Indicate by mark whether the Registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities
Exchange Act 1934 during the preceding 12 months (or for such
shorter period that the Registrant was required to file such
reports), and (2) has been subject to such filing requirements
for the past 90 days.
 [ X ] YES                                    [   ] NO
As of October 26,1998, the Registrant had 15,711,877 shares of
Common Stock, no par value, outstanding, and  the aggregate
market value of the shares held by non-affiliates on that date
was $29,563,000 based upon the last sales price of the
Registrant's Common Stock reported on the American Stock
Exchange.*

Indicate by check mark if disclosure of delinquent filers
pursuant to Item 405 of Regulation S-K is not contained herein,
and will not be contained, to the best of the Registrant's
knowledge, in definitive proxy or information statements
incorporated by reference in Part III of this Form 10-K or any
amendment to this Form 10-K. [X]
_______________

* Excludes 3,264,437 shares of Common Stock held by directors,
executive officers and shareholders whose beneficial ownership
exceeds ten percent of the shares outstanding on October 26,
1998. Exclusion of shares held by any person should not be
construed to indicate that such person possesses the power,
direct or indirect, to direct or cause the direction of the
management or policies of the Registrant, or that such person is
controlled by or under common control with the Registrant.

DOCUMENTS INCORPORATED BY REFERENCE
Portions of the Registrant's Proxy Statement for the 1999 Annual
Meeting of Shareholders to be filed on or before November 28,
1998 are incorporated by reference into Part III.


PART I.

Item 1. Business.

Except for the historical information contained herein, the
following discussion contains forward-looking statements that
involve risks and uncertainties. The Company's actual results
could differ materially from those discussed here. Factors that
could cause or contribute to such differences include, but are
not limited to, those discussed in the description of the
Company's business below and the sections entitled "Licenses",
"Manufacturing", "Sales and Marketing", "Competition",
"Government Regulation", "Patents and Proprietary Rights" and
"Management's Discussion and Analysis of Financial Condition and
Results of Operations", those discussed in the S-3 Registration
Statement File No. 333-25661 filed with U.S. Securities and
Exchange Commission, as well as those discussed in any documents
incorporated by reference herein or therein.

General

Cypros Pharmaceutical Corporation (the "Company") is a specialty
pharmaceutical company which develops and markets products for
the critical care market. The Company's sales and marketing force
is currently marketing three products, Glofil and Inulin, two
injectable drugs that assess kidney function by the measurement
of glomerular filtration rate, and Ethamolin, an injectable drug
that treats bleeding esophageal varices. In addition, the Company
intends to launch two burn/wound care products, Neoflo and
Sildaflo, in the next year. The Company's development programs
target ischemic (impaired blood flow) disorders and the Company
is currently conducting a Phase III clinical trial on Cordox
(formerly CPC-111) in sickle cell crisis patients. The Company is
also planning (i) Phase III clinical trials of Cordox in other
ischemic disorders, such as coronary artery bypass grafting
surgery ("CABG") and (ii) other pivotal clinical trials of
Ceresine in closed head injury patients.

Acquisitions of Approved Products to Build Commercial
Capabilities.  The Company has an 11-person sales and marketing
force directed at the critical care market. In advance of the
potential approval of Cordox and Ceresine by the U.S. Food and
Drug Administration ("FDA"), the Company is building a sales,
marketing and distribution capability through the acquisition of
already approved products; Glofil-125 and Inulin, which it
acquired in August 1995, and Ethamolin, which it acquired in
November 1996 from Schwarz Pharma, Inc. In November 1997, the
Company acquired a patented drug delivery technology, Dermaflo,
and two FDA-approved products, Neoflo and Sildaflo, which it is
planning to launch during the next year into the burn and wound
care markets.  The Company will continue to build its sales and
marketing force as it completes additional acquisitions. During
the fiscal year ended July 31, 1998, the net sales of the
Company's three acquired products reached $3,446,000, a 42%
increase over the $2,428,000 recorded during the prior fiscal
year.

Cordox and Ceresine: Ischemia Therapies in Late Stage Development
Serving Unmet Medical Needs. There are several million cases of
ischemia-induced disorders annually in the United States,
resulting in over seven hundred thousand deaths and several
billion dollars in annual costs for physical and mental
rehabilitation and ongoing care, and yet there are currently no
FDA-approved drugs to avoid or reverse the massive cell damage
caused by ischemia (termed "cytoprotective drugs").  Ischemic
disorders include heart attack, stroke, surgery, trauma and
various anemias. Currently approved drugs for treating
cardiovascular ischemia, such as "clot busting" drugs, serve to
re-establish blood flow but do not have direct cytoprotective
effects on the ischemic tissue. The Company believes that the
drugs it is developing, Cordox and Ceresine, if approved by the
FDA and successfully marketed, should reduce significantly the
number of fatalities and the rehabilitation and ongoing care
costs associated with ischemic disorders.

Impairment of blood flow reduces the supply of oxygen to body
cells, interrupting normal aerobic metabolism and causing
depletion of adenosine triphosphate ("ATP"), the cells' primary
energy source.  Ischemia-induced depletion of ATP produces a
myriad of increasingly destructive cellular events known as the
"toxic ischemic cascade."  The Company believes that the
cytoprotective drugs under development by others for treatment of
ischemia are focused on treating specific elements of the toxic
ischemic cascade, leaving other elements free to cause cell,
tissue and organ damage.

The Company's approach, based on preventing or reversing the
toxic ischemic cascade, is comprehensive in nature and, the
Company believes, potentially more effective. Cordox and Ceresine
are designed to act during and after ischemia by maintaining
cellular ATP levels or accelerating their restoration. Cordox (a
natural substance) and Ceresine are more amenable to being used
early in the patient management process, which is critical in
acute care settings.

Further, Cordox and Ceresine are small molecules, easily
deliverable and inexpensive to produce. Significant human data,
available from the Company's own studies and independent,
physician-sponsored Investigational New Drug applications
("INDs"), show that each of these drugs is well tolerated when
administered at clinically relevant doses to healthy subjects.
The minimal side effects associated with Cordox and Ceresine
should reduce their development risk and may permit their broad,
early use in acute care settings, such as emergency rooms, where
rapid access to treatment is of utmost importance.

During the fiscal year ended July 31, 1998, the Company released
positive data in its Phase II trial of Cordox in sickle cell
anemia crisis patients, completed and filed a Phase III protocol
with the FDA and began recruiting clinical trial sites for the
Phase III trial. In addition, the Company also filed a U.S.
patent application during the year based upon the data from the
Phase II trial and in September 1998 was informed by the U.S.
Patent and Trademark Office that all claims had been allowed.
This patent provides specific coverage for the use of Cordox in
sickle cell anemia crisis patients to reduce the painful
occlusive ischemic episodes.

Pre-clinical Programs Focused on Ischemic Disorders. Further
implementing its overall strategy of developing drugs that
protect cells from ischemic damage, the Company is conducting pre-
clinical studies on additional compounds intended to reduce the
neurodegeneration associated with stroke and traumatic head
injury.  The Company believes that these drugs may reduce
"excitotoxicity," the excess release of excitatory amino acid
("EAA") neurotransmitters in the brain that stems from
ischemically-caused ATP depletion in certain brain cells.  Drugs
being developed in these studies include:  (i) a new class of
neuronal calcium channel blockers which block excessive EAA
neurotransmitter release;   (ii) a patented series of novel
compounds which augment levels of adenosine (a naturally
occurring substance which inhibits EAA release) in ischemic
tissue by inhibiting its metabolism for which the Company
received a $100,000 Small Business Innovation Research Phase I
grant during the past year; and (iii) a novel series of compounds
which inhibit the release of EAA (especially glutamate) from
glial cells in the brain. The Company is attempting to develop
lead compounds from all three of the above pre-clinical programs
to treat a variety of ischemic disorders of both the
cardiovascular and cerebrovascular systems.

The Company is also pursuing the development of Cordox prodrugs
with improved pharmacokinetic and pharmacodynamic properties that
will permit oral delivery of Cordox and also access to the
central nervous system.

Acquired Pharmaceutical Products

The Company's strategy includes building near-term sustainability
with the cash flow from acquired pharmaceutical products with the
goal of reducing its overall cash consumption rate and building
its sales, marketing and distribution infrastructure in advance
of the potential approval of Cordox and Ceresine by the FDA.

Glofil-125 and Inulin.   Kidney disease afflicts more than 2
million persons in the United States and is increasing primarily
due to the growth in diabetes and systemic lupus erythromatosis
cases. Kidney disease results in over $12 billion annually in
healthcare costs in the United States. The measurement of kidney
function (glomerular filtration rate or "GFR") is critical to the
understanding of the disease state and its appropriate
therapeutic intervention.  GFR has historically been estimated by
the measurement of endogenous serum creatinine and by creatinine
clearance.  These diagnostic assays overestimate kidney function
by as much as 100 percent in patients. The Company believes that
the injection of a renal filtration marker, such as Inulin and
Glofil-125, is the most accurate and direct means of determining
GFR.

Glofil-125 and Inulin are FDA-approved products for the
measurement of GFR. Nephrologists and nuclear medicine
departments at major medical centers are the primary users of
these products. During the fiscal year ended July 31, 1998, the
Company recorded sales from these two products of $1,227,000 and
one customer using Glofil-125 for clinical trials of a renal
therapeutic accounted for 33% of these sales and 12% of the
Company's total sales. That customer has terminated those trials
and the Company expects its sales of Glofil to suffer for the
next six to nine months.

Glofil-125 is an injectable radioactive diagnostic drug, which
provides rapid information on GFRs with great accuracy. It is
currently sold by the Company in 4ml vials and in prefilled
syringes through the 117 nationwide radiopharmacies of Syncor
International pursuant to a distribution agreement entered into
with the Company in February 1996. Inulin is an injectable
diagnostic drug, which provides a  measure of GFRs. Inulin  is
currently sold in 50 ml ampules with actual patient dosing
correlated to patient weight.

The Company believes there is substantial opportunity for
increased utilization of Glofil-125.  Present diagnostic
procedures for measuring kidney function include serum creatinine
and creatinine clearance tests.  These two tests are the most
commonly performed methods of measuring kidney function because
of their low cost, however both methods significantly
overestimate kidney function in the estimated 500,000 patients
with severe renal disease.  The use of Glofil-125 has been
established in published clinical studies as being a more direct,
true measure of kidney function yielding much more accurate
results than serum creatinine or creatinine clearance tests.
This improved accuracy can be essential to reliably monitoring
disease progression and intervention, as well as assessing renal
impairment in its early and most treatable stage.

In addition, the serum creatinine test involves blood draws and
an average time of 3-4 hours to complete, and the creatinine
clearance test involves 24-hour urine collection, followed by an
additional 3-4 hours of analysis time. The Company is currently
funding a clinical study of Glofil-125 at the University of Texas
Southwest Medical Center to prove the viability of a 45 minute
test. If the study is successful, the Company believes that
Glofil will have a significant competitive advantage over the
other tests.

The biggest impediment to the continued growth in the sales of
Glofil-125 would be a change in the ability of the end users to
obtain reimbursement for the test or the inability of the Company
to include Glofil in the protocols of other clinical studies of
renal therapeutics.

Inulin, which is sold by the Company, and 99mTc-DTPA (which is
not sold by the Company and must be prepared onsite by the end
user) are alternative agents for GFR measurement, however the
preparation and use of these two drugs is difficult and they do
not provide the practical advantages of Glofil-125.  The Company
is aware of no new diagnostic drugs being introduced or in
development that the Company is aware of as a competitive threat
to Glofil-125.

Ethamolin.     Approximately 75,000 people in the United States
have or are approaching end stage liver disease.  Liver disease
(hepatic cirrhosis) results in approximately 25,000 deaths
annually and ranks ninth among the leading causes of death.
Hepatic cirrhosis promotes the formation of esophageal varices
through development of portal hypertension.  When intravenous
blood pressure rises, these varicosities may cause a life
threatening form of upper gastrointestinal  hemorrhage associated
with a 35-50% mortality rate.  At least 50,000 patients in the
United States either have actively bleeding esophageal varices or
are at imminent risk of bleeding.

Early and effective treatment of esophageal varices to achieve
hemostasis is essential to the outcome of the bleeding patient.
The most common pharmaceutical treatment protocol involves the
injection of a sclerosing agent into the varix, achieving clot
formation and obliteration of the varix.  This form of hemostasis
is called sclerotherapy and usually requires multiple treatment
sessions.  Ethamolin is the only sclerotherapy agent cleared by
the FDA for the treatment of bleeding esophageal varices and has
recently become the market leader in this therapeutic category.
During the fiscal year ended July 31, 1998, the Company recorded
sales from this product of $2,296,000 and one wholesaler
accounted for 35% of these sales and 23% of total sales.
However, there is strong competition from another drug,
Sotradecol, which is being prescribed off-label, and from band
ligation, a form of surgery.

The Dermaflo Technology and the Neoflo and Sildaflo Products.  In
November 1997, the Company acquired the Dermaflo technology, a
patented topical drug delivery system, from Enquay, Inc. for a
combination of cash and royaties on net sales. The technology is
a polymer matrix system that can store a variety of different
drugs and release them at a desired rate over an extended period
of time so that optimal clinical response is obtained. Included
in the assets acquired were two FDA-approved products, Neoflo and
Sildaflo, and a substantial amount of manufacturing equipment.

Neoflo and Sildaflo, the first two products that the Company
expects to launch using the Dermaflo technology address consumer
needs in both the over-the-counter and acute care markets. Neoflo
is a dressing that incorporates the triple antibiotic, polymyxin
B sulfate, bacitracin zinc and neomycin sulfate. The Company
intends to manufacture Neoflo in various sizes, small sizes to
address the over-the-counter market (through a distributor) and
larger sizes for the hospital market. Sildaflo is a dressing that
incorporates silver sulfadiazine, the most widely-used topical
antimicrobial for the treatment of burns. The Company intends to
manufacture Sildaflo in various large sizes to address the
hospital/burn clinic market. Initially, the Company intends to
address the critical care markets with its own sales force.

The Company believes the extended-release nature of the
technology will result in decreased treatment-related costs,
increased patient compliance and reduced pain and discomfort,
resulting in a marketing advantage for the products sold using
the Dermaflo technology. While it is difficult to determine the
market potential of Neoflo and Sildaflo, it is known that silver
sulfadiazine and the triple antibiotic have combined sales of
approximately $60 million in the United States in their non-
controlled-release forms.

The Company will be manufacturing the Dermaflo products itself,
has located a facility in Kansas City, Missouri for that purpose,
has installed some of the equipment in that facility and is
beginning to manufacture test batches of the Neoflo product. The
facility will require tenant improvements and a series of
validations to manufacture the Sildaflo product, and therefore,
the Company believes that Neoflo in both its over-the-counter and
acute care sizes will be on the market before Sildaflo. Both
products are expected to be on the market in the next year.

Cytoprotection Market Opportunities

Cytoprotective drugs for acute care settings that treat ischemic
injury are not currently available and the market opportunities
for the Company's drugs are large, totalling several million
cases annually in the United States. The Company believes that
its drugs, if approved, could substantially reduce not only the
large number of fatalities associated with ischemia-related
disorders but also reduce significantly the billions of dollars
spent annually in rehabilitation and ongoing care in the United
States of these victims.

The Company's drugs are designed to be administered intravenously
in order to speed their delivery to the ischemic tissue. In order
to ensure early interventions, they are intended to be standard
components in hospital emergency rooms, operating theater suites,
endoscopy suites and radiology suites. Their lack of acute
toxicity should  suit them for this purpose.

Circulatory System Ischemia. Cardiovascular ischemia can result
in a spectrum of clinically significant events ranging from
angina (pain) to heart attack and sudden death.  In addition to
the numerous trauma or disease related causes of ischemia, there
are a variety of voluntary surgical procedures which result in
ischemia to vital organ systems.  Procedures such as coronary
artery bypass grafting surgery, which are performed to improve
blood flow to the heart, induce temporary ischemia which can
result in tissue damage.  Thus, Cordox, if approved, could also
be a part of the treatment regimen for these disorders. All of
these conditions or procedures represent potential opportunities
for use of the Company's drugs to reduce the tissue damage known
to be associated with them.

Cerebrovascular ischemia (stroke) can result in temporary loss of
consciousness, permanent behavioral and neurologic impairment,
coma and death. Traumatic injury to the head is caused by
accidents, near drownings and similar incidents. The resultant
medical problems are, in large part, caused by ischemia to the
brain.  The biochemical processes associated with stroke and head
trauma are thought to be very similar; thus, the Company expects
drugs developed for one indication to be useful for the other.

Sickle Cell Anemia.  Sickle cell anemia is an autosomal recessive
genetic disease carried by about 8% of African-Americans and a
lesser number of people native to the Mediterranean region.
Approximately 72,000 African-Americans suffer from the most
severe form (homozygous) of the disease, where the red blood
cells form "sickle" shapes that can occlude capillaries and
result in severe and disseminated ischemia (termed vaso-occlusive
events or "VOE"). Most sickle cell patients undergo multiple VOEs
each year. Cordox has been shown pre-clinically to help reduce
this "sickling" process and to reduce pain in sickle cell disease
patients. The Company is  evaluating it in a Phase III trial of
sickle cell anemia crisis patients. The FDA has granted orphan
drug designation to Cordox in this indication.

The Pathology of Ischemia

Metabolic Aspects (All Tissues).  All living animal cells require
glucose and oxygen to survive, both of which are supplied to
tissues by the blood.  Glucose is transformed into carbon dioxide
and water with the resultant formation of  ATP.  ATP is the
universal fuel which is required to keep the cell alive.  During
and after ischemia, the decrease in cellular ATP levels damages
the cell and, the Company believes, results in the toxic ischemic
cascade, a myriad of cell-damaging processes discussed below
which cause further cell damage.

ATP generation occurs in two phases. The first phase, called
glycolysis or anaerobic metabolism, does not require oxygen.  The
second phase, called aerobic metabolism or the Krebs cycle,
requires oxygen and occurs in mitochondria. Glycolysis is a means
of producing cellular energy in ischemic conditions, and
therefore, represents the body's natural defense against ischemic
damage. For this reason, the facilitation of glycolysis is of
interest therapeutically in the prevention of ischemic damage to
tissues and organs. When pyruvic acid builds up during ischemia
due to the inability of aerobic metabolism to utilize it, an
enzyme converts it to lactic acid which blocks glycolysis. The
therapeutic principle underlying Cordox and Ceresine is to
facilitate glycolysis during and after ischemia so the cell
continues to produce ATP and the toxic ischemic cascade is pre-
empted or reversed. Specifically, Cordox bypasses the lactic acid
block and does not need to be energized by ATP to be metabolized.
Ceresine reduces ischemia induced lactic acid accumulation by
removing the cause of the metabolic block, and therefore, allows
energy metabolism to continue.

Excitotoxicity (Nerve Tissue).  The destructive impact of ATP
depletion in nerve tissue is further complicated by the
over-production in nerve cells of various excitatory amino acids,
chemicals that transmit nerve impulses from one nerve cell to
another.  The over-production and release of EAAs (predominately
glutamate and aspartate) by nerve cells exposed to ischemia over-
stimulates adjacent postsynaptic nerve cells, causing them in
time to succumb to metabolic exhaustion and cell death.  This
ischemia-induced process, called delayed excitotoxicity, is
associated with a number of acute (stroke and traumatic head
injury) and chronic (Alzheimer's, Parkinson's Disease and
Amyotrophic Lateral Sclerosis) neurologic disorders. Controlling
delayed excitotoxicity by blocking the postsynaptic EAA receptors
has recently attracted the attention of both academic and
pharmaceutical scientists. To date, the drugs in development that
act by this mechanism have considerable side effects and only
block selected receptor subtypes, therefore only dealing with
part of the problem since all receptor subtypes appear to cause
damage.

Recent evidence has shown that specific presynaptic channels,
neuronal calcium channels, regulate the release of
neurotransmitters in nerve cells.  The Company has shown that
compounds which block excessive EAA neurotransmitter release from
nerve cells greatly reduce excitotoxicity and post-ischemic
tissue damage in animal models of stroke and head trauma.  The
Company is seeking to develop drugs that specifically block
neuronal calcium channels and therefore, if successful, would
block the excitotoxic process and reduce the resultant cell
damage. These drugs are believed to have a more comprehensive
effect on excitotoxicity than the specific postsynaptic EAA
receptor blockers, since they will reduce the stimulation of all
and not just some EAA receptors.

The Company has also shown that adenosine, a natural compound,
has cytoprotective properties. The Company is seeking to develop
a series of drugs, called adenosine metabolism inhibitors, which,
if successful, would augment adenosine levels in ischemic tissue
and have cytoprotective effects in both brain and heart tissue.
See "Adenosine Metabolism Inhibitor Program."

Additionally, the Company is developing a novel series of
compounds which inhibit the release of EAA (especially glutamate)
from glial cells in the brain.

The Toxic Ischemic Cascade.   Ischemia-induced cell damage
triggers a number of processes which cause further damage to each
affected cell and its surrounding cells.  This myriad of
destructive processes is facilitated by reperfusion injury, which
occurs after blood flow is re-established. The traumatized,
ATP-depleted cell enters into the toxic ischemic cascade,
resulting in the release of a host of toxic agents, including
damaging reactive chemicals called free radicals, as well as
other molecules that are products of cell membrane breakdown,
all of which damage cells.  Excessive intracellular calcium
buildup is also an element of the toxic ischemic cascade and also
triggers a host of other damaging processes, such as activation
of proteolytic enzymes which break down proteins and digest cells
and activation of protein kinases which regulate cell metabolism.
The traumatized cell also releases agents which stimulate the
immune system, activating various blood cells, such as
neutrophils and macrophages which actually eliminate the cell
affected by ischemia. Rather than target each of these myriad
events, the Company's drugs, Cordox and Ceresine, address ATP
replenishment so that the cell can correct the ischemic cascade
naturally.

There are currently no known FDA-approved cytoprotective drugs.
Those under development are, to the Company's knowledge,
primarily aimed at specific elements of the toxic ischemic
cascade.  The Company believes that its approach to
cytoprotective drug development is unique in that it seeks to pre-
empt or reverse the entire cascade by decreasing the initial
metabolic trauma which triggers it (i.e., ATP depletion).  The
Company believes that this approach is preferable to treating
specific elements of the cascade, since it more comprehensively
addresses the underlying pathology and should therefore result in
more efficacious therapy.

Cardiovascular and Cerebrovascular Ischemia Drugs in Development-
The Metabolism Program

The Company is starting a Phase III clinical trial on Cordox in
sickle cell crisis patients. The Company has also released
substantial amounts of data from its CABG trial of Cordox and its
traumatic head injury trial of Ceresine and is planning Phase III
trials in both of these indications.

Cordox.  Cordox is a small phophoryllated sugar that the Company
believes (based on extensive pre-clinical and mechanistic data)
stimulates and maintains glycolysis in cells undergoing ischemia
by circumventing the ischemia-induced blockage of this process.
The drug also appears to inhibit various aspects of immune system
activation which underlie reperfusion injury. The Company has
licensed or obtained several issued U.S. patents which cover the
use of Cordox in several  acute ischemic indications and a U.S.
patent on a novel formulation of Cordox.

There are numerous published U.S. and foreign clinical studies
with Cordox, where more than 500 patients were administered the
drug, indicating that Cordox is well tolerated in humans with
little or no side effects. These studies indicate that the drug
improves heart function and recovery in various ischemic
situations where the heart is injured.  In addition, 317 patients
have participated in the four Phase II trials of Cordox under the
Company's IND and the drug continues to be well tolerated.

A total of 125 CABG patients participated in the Company's double-
blind, placebo-controlled Phase II trial, and the data released
demonstrates that in patients receiving the active drug, Cordox
(a) has a cardioprotective effect on heart muscle, (b) improves
key parameters of heart function, including cardiac output, left
ventricular stroke work index and cardiac index and (c) reduces
the need for inotope support post-operatively in the intensive
care unit (the "ICU") and results in  shorter patient stays in
the ICU.

In October 1997, the Company released positive data from a 47-
patient double-blind, placebo-controlled,  dose-ranging Phase II
clinical trial with Cordox in sickle cell anemia crisis patients
showing that the drug significantly reduced pain during crisis
using two different measures of pain, the visual analog scale and
the categorical assessment scale.

Ceresine.  Ceresine is also a small non-peptide molecule which
acts on glycolysis at a different site from Cordox.  The Company
has licensed or obtained two issued U.S. patents covering the use
of Ceresine in cerebral ischemia. The Company believes that
Ceresine stimulates a specific enzyme which is present in the
membrane of mitochondria that removes a precursor of lactic acid
(pyruvic acid) from the cytoplasm of the cell by transporting it
into the mitochondria and converting it to acetyl coA. This
results in a reduction of lactic acid in the cell. Increased
post-ischemia accumulation of lactic acid is a major causal
factor in the cessation of glycolysis, the resultant decrease in
cellular ATP levels and eventual cell death.  Numerous studies
have shown that Ceresine reduces post-ischemia lactic acid levels
in humans subjected to various traumatic events which would
otherwise have resulted in increased lactic acid (lactic
acidosis).

Ceresine has been employed by clinical investigators in patients
on an experimental basis for the intravenous treatment of lactic
acidosis.  Published clinical studies and the Company's own Phase
I data have established that Ceresine reduces serum lactic acid
and exhibited no serious side effects at the dose levels in that
study.  It has also been shown in human studies to permeate the
blood-brain barrier and to reduce brain lactic acid levels in
congenital lactic acidosis patients.

The Company's Phase II clinical trial data on Ceresine in closed
head injury patients showed that the drug crosses the blood-brain
barrier at high levels and very quickly thereafter reduces brain
lactate levels substantially. This effect lasted for at least 12
hours. Serum lactate levels were also reduced substantially in
the drug-treated group.  The strength of this data has led the
Company to announce that it will pursue the Phase III development
of Ceresine in this indication and in July 1998, the FDA granted
expedited development status to Ceresine in head injury under
Subpart E of the FDA regulations.  In addition, the Company has
completed enrollment in a Phase II clinical trial on Ceresine in
stroke patients. 103 patients have participated in the Phase I
and two Phase II trials of Ceresine under the Company's IND and
the drug continues to be well tolerated.


Ischemia Drugs in Pre-clinical Research-The Metabolism and
Excitotoxicity Programs

The Company is also seeking to develop new drugs for the
treatment of ischemia-related disorders involving neurological
damage, such as stroke, traumatic head injury, epilepsy and
chronic neurodegenerative disorders such as Alzheimer's and
Parkinson's disease.  These pre-clinical research programs are
focused on either the metabolic or the excitotoxicity aspects of
ischemia therapeutics, and involve the chemical modification of
identified lead molecules that regulate adenosine metabolism,
various calcium ion channels on neuronal cells and chloride
channels on glial cells.

Adenosine Metabolism Inhibitor Program. The Company is seeking to
develop CPC-405 and certain of its derivatives, which are novel
small molecules with demonstrated potency as inhibitors of
adenosine metabolism. Adenosine is a natural cytoprotective agent
which is generated in ischemic tissue and serves to protect cells
from a variety of traumatic situations. Naturally generated
adenosine is rapidly degraded by enzymes. The Company expects
that CPC-405 will increase the level of adenosine in tissue
traumatized by ischemia and thereby increase its cytoprotective
effect. A U.S.  patent has been issued on the composition of the
CPC-400 series of drugs. During the past yeart, the Company
licensed an additional U.S. patent from the University of Rhode
Island which covers the composition of additional CPC-400 series
compounds.

Neuronal Calcium Channel Blocker Program.  The Company believes
that the therapeutic approach to excitotoxicity currently
attracting the most commercial attention involves the development
of specific EAA receptor blockers which inhibit the excessive
postsynaptic EAA action that is triggered by ischemia.  Although
these EAA receptor blockers have neuroprotective properties in
cell culture and animal models of ischemia, their usefulness is
hampered by toxic side effects associated with the blockage of
EAA receptors and by the fact that there are multiple EAA
receptor subtypes, all of which appear to cause post-ischemic
damage when they are excessively stimulated.  Also, a number of
these EAA receptor blockers have recently failed in various
stroke and head injury clinical trials.

The Company is seeking to develop new classes of drugs that are
designed to remedy excitotoxicity in a potentially more complete
and effective manner by reducing EAA release from nerve cells,
thereby reducing the over-stimulation of all EAA receptor
subtypes. This pre-synaptic approach to neuroprotection is viewed
by the Company as potentially more effective than blocking
receptors post-synaptically.

Specifically, the Company is seeking to develop separate classes
of small-molecule drugs that act as neuronal calcium channel
blockers, which it has labelled as the CPC-300,  CPC-800 and CPC-
8000 series and has synthesized over 100 compounds in this
series. If successful, these drugs would have the ability to
normalize or decrease EAA release and thereby comprehensively
reduce the over-stimulation of EAA receptors. Prototype agents
such as CPC-8027 have shown the desired effect of acting at the
neuronal calcium channels, which controls EAA release. The
Company has demonstrated neuroprotection in several pre-clinical
models with CPC-304, CPC-317, CPC-877 and CPC-8027 and intends to
further modify them structurally with the goal of improved drug
delivery to the central nervous system.  These modifications will
require additional pre-clinical testing.

Glial Chloride Channel Blockers.  The Company has synthesized a
series of agents designated as the CPC-700 series. These agents
act to inhibit glial cell swelling in the brain which occurs
after injury in disorders such as stroke and head injury. These
agents inhibit the excess release of EAAs from glial cells and
have demonstrated neuroprotective properties. The Company is
currently filing patents on these compounds.

Licenses

The Company believes its strategic objectives can best be met by
combining its in-house research and development efforts with
licenses and research collaborations with scientists at outside
academic and clinical research centers.

The principal sources of the Company's existing licenses are:

Angel K. Markov, M.D.

Cordox.  The Company has obtained an exclusive license from Dr.
Markov to four U.S. patents covering the use of Cordox in a
number of ischemic indications.  As part of the license, the
Company is funding clinical development in Dr. Markov's
laboratories at the University of Mississippi Medical Center.  In
this regard, the Company has undertaken certain development
obligations which must be met in order to maintain this license
in force.  In the event the Company breaches the license
agreement, such as by not meeting certain milestones within the
specified time periods or by failing to expend certain amounts in
connection with clinical trials within specified time periods,
the license will automatically terminate and all rights under the
license and information acquired by the Company concerning any
products based on the licensed technology will revert to Dr.
Markov.  In the event of such termination, the Company will
retain the rights to market products for which sales occurred
within the calendar year prior to the termination, and all other
products and information related thereto based on the licensed
technology will revert to Dr.  Markov. To date, the Company has
met all such milestones.

University of Cincinnati

Ceresine.  The Company has an exclusive license from the
University of Cincinnati ("UC") to a U.S. patent covering the use
of Ceresine in cerebral ischemia.  The Company has undertaken
certain development obligations which must be met in order to
maintain its rights in force.  If certain milestones are not met
by the Company within specified time periods, UC may, in its sole
discretion, elect to continue the agreement, negotiate in good
faith with the Company to modify the agreement or terminate the
agreement upon 30 days' written notice in which event all rights
under the license would revert to UC.  To date, the Company has
met all such milestones.

Manufacturing

The Company does not currently manufacture any of its acquired
products or its products in development but is undertaking to
manufacture the Dermaflo products.  The finished forms of Glofil,
Inulin, Ethamolin, Cordox and Ceresine are manufactured for the
Company under contract by established manufacturers and
alternative manufacturers have been qualified for Cordox and
Ceresine. In the case of Inulin, Cordox and Ceresine, the Company
is responsible for obtaining the bulk drug from a third party and
delivering it to the finished goods manufacturer. In the case of
Inulin and Ceresine, the Company has qualified alternative
sources of supply for the bulk drug.  There can be no assurance
that any of the Company's bulk or finished goods contract
manufacturers will continue to meet the Company's requirements
for quality, quantity and timeliness or the FDA's current Good
Manufacturing Practice ("cGMP") requirements or that the Company
would be able to find a substitute bulk manufacturer for Cordox,
or a substitute finished goods manufacturer for Inulin, Glofil
and Ethamolin or any other of its products which would meet these
requirements or that lots will not have to be recalled with the
attendant financial consequences to the Company.

In addition, the Dermaflo product line is the Company's first
attempt at in-house manufacturing of any of its products and
there can be no assurance that the Kansas City facility will be
completed, or when completed, will be approved by the FDA, or
when approved will have the capacity to meet demand. Although the
Company believes the facility will meet cGMP requirements, the
Company has not manufactured any products using the Dermaflo
technology yet in the facility. The Company also faces risks
inherent in the operation of a single facility for the
manufacture of Dermaflo products, including risks of unforeseen
plan shutdowns due to personnel, equipment or other factors. Any
delay in the manufacturing of Dermaflo products could result in
delays of product shipments, which could have a material adverse
effect on the Company's business, financial condition and results
of operations. Further, the Company is relying on third parties
to supply it with the active ingredients for the Neoflo and
Sildaflo products in bulk form, and there can be no assurance
that such third parties may not cause delays in the manufacture
or shipments of these Dermaflo products.

The Company's limited manufacturing experience and its dependence
upon others for the manufacture of bulk or finished forms of its
products may adversely affect the future profit margin, if any,
on the sale of those products and the Company's ability to
develop and deliver products on a timely and competitive basis.
In the event the Company is unable to manufacture its products,
directly or indirectly through others, on commercially acceptable
terms, it may not be able to commercialize its products as
planned.

Sales and Marketing

The Company currently has a director of marketing, a customer
service representative, a product manager, a national sales
manager and six field sales representatives for Glofil, Inulin
and Ethamolin and is hiring additional sales representatives.
The Company believes that it will be able to serve the hospital
market in North America  with a 50 to 70 person sales and
marketing staff. There can be no assurance that the Company will
be able to establish sales and distribution capabilities or be
successful in gaining market acceptance for its drugs.

Competition

The Company faces competition from specialized biotechnology
companies, pharmaceutical companies of all sizes, academic
institutions, government agencies and public and private research
organizations, many of which have extensive resources and
experience in research and development, clinical testing,
manufacturing, regulatory affairs, distribution and marketing.
Some of these entities have significant research activities in
areas upon which the Company's programs focus.  Many of the
Company's competitors possess substantially greater research and
development, financial, technical, marketing and human resources
than the Company and may be in a better position to develop,
manufacture and market drugs.  These entities may discover and
develop drugs competitive with or superior to those developed by
the Company.

Government Regulation

The manufacture and sale of the Company's products are subject to
extensive regulation by United States and foreign governmental
authorities prior to commercialization.  In particular, drugs are
subject to rigorous preclinical and clinical testing and other
approval requirements by the FDA, state and local authorities and
comparable foreign regulatory authorities.  The process for
obtaining the required regulatory approvals from the FDA and
other regulatory authorities takes many years and is very
expensive.  There can be no assurance that any produuct developed
by the Company will prove to meet all of the applicable standards
to receive marketing approval in the United States or abroad.
There can be no assurance that any such approvals will be granted
on a timely basis, if at all.  Delays and costs in obtaining
these approvals and the subsequent compliance with applicable
federal, state and local statutes and regulations could
materially adversely affect the Company's ability to
commercialize its products and its ability to receive sales
revenues.

The research activities required by the FDA before a drug can be
approved for marketing begin with extensive preclinical animal
and laboratory testing.  The tests include laboratory evaluation
of product chemistry and animal studies for the safety and
efficacy of the drug.  The results of these studies are submitted
to the FDA as part of an IND which is reviewed by the FDA prior
to beginning clinical trials, first in normal volunteers and then
in patients with the disease.

Clinical trials involve the administration of the investigational
new drug to healthy volunteers or to patients, under the
supervision of a qualified physician/principal investigator.
Clinical trials are conducted in accordance with governmental
statutes, regulations and guidelines and under protocols that
detail the objectives of the study, the parameters to be used to
monitor safety and the efficacy criteria to be evaluated.  Each
protocol must be submitted to the FDA as part of the IND.
Further, each clinical study must be evaluated by an independent
Institutional Review Board ("IRB") at the institution at which
the study will be conducted.  The IRB considers, among other
things, ethical factors, the safety of human subjects and the
possible liability of the institution, and approves the informed
consent to be obtained from all subjects and patients in the
clinical trials.  The Company will have to monitor the conduct of
clinical investigators in performing clinical trials and their
compliance with FDA requirements.

Clinical trials are typically conducted in three sequential
phases (Phase I, Phase II and Phase III), but such phases may
overlap.  There can be no assurance that Phase I, Phase II or
Phase III testing will be completed successfully within any
specified time period, if at all, with respect to any of the
Company's drugs.  Furthermore, the Company or the FDA may suspend
clinical trials at any time if it is felt that the subjects or
patients are being exposed to an unacceptable health risk or that
the investigational product lacks any demonstrable efficacy.

The results of the pharmaceutical development, preclinical
studies and clinical studies are submitted to the FDA in the form
of a New Drug Application ("NDA") for approval of the marketing
and commercial shipment of the drug.  The testing and approval
process is likely to require substantial time (frequently five to
eight years or more) and expense and there can be no assurance
that any approval will be granted on a timely basis, if at all.
The FDA may deny an NDA if applicable regulatory criteria are not
satisfied, require additional testing or information, or require
post-marketing testing and surveillance to monitor the safety of
the Company's drugs.  Notwithstanding the submission of the NDA
and any additional testing data or information, the FDA may
ultimately decide that the application does not satisfy its
regulatory criteria for approval.  Finally, drug approvals may be
withdrawn if compliance with labeling and cGMP regulatory
standards is not maintained or if unexpected safety problems
occur following initial marketing.

Among the conditions for clinical studies and NDA approval is the
requirement that the prospective manufacturer's quality control
and manufacturing procedures conform to cGMP, which must be
followed at all times.  In complying with standards set forth in
these regulations, manufacturers must continue to expend time,
monies and effort in the area of production and quality control
to ensure full technical compliance.

Also, the Prescription Drug Act of 1997 requires that companies
engaged in pharmaceutical development, such as the Company, pay
user fees of at least $100,000 upon submission of an NDA. In
addition to regulations enforced by the FDA, the Company is
subject to regulation under the Occupational Safety and Health
Act, the Environmental Protection Act, the Toxic Substances
Control Act, the Resource Conservation and Recovery Act and other
present and potential future federal, state or local regulations.
For marketing outside the United States, the Company is subject
to foreign regulatory requirements governing human clinical
trials and marketing approval for drugs.  The requirements
governing the conduct of clinical trials, product licensing,
pricing and reimbursement vary widely from country to country.

Patents and Proprietary Rights

The Company's success may depend in large measure upon its
ability to obtain patent protection for its products, maintain
confidentiality and operate without infringing upon the
proprietary rights of third parties.  The Company has obtained
patent coverage, either directly or through licenses from third
parties, for certain of its products. The Company currently owns
or has licensed a total of 13 U.S and foreign patents covering
Cordox and Ceresine in a variety of ischemic disorders. It also
holds an exclusive license to 5 U.S. and foreign patents on the
Dermaflo technology, 2 issued U.S. patents on adenosine
metabolism inhibitors, 2 issued U.S. patents on the use of
disulfiram in ischemic disorders and an issued U.S. patent of
aminoglycosides as neuroprotective agents.

In addition to the patents issued and allowed as mentioned above,
the Company has also filed several other patent applications in
the United States and abroad on its various products and expects
to file additional applications in the future.  There can be no
assurance that any of these patent applications will be approved,
except where claims have already been examined and allowed, or
that the Company will develop additional proprietary products
that are patentable.  Nor can there be any assurance that any
patents issued to the Company or its licensors will provide the
Company with any competitive advantages or will not be challenged
by third parties or that patents issued to others will not have
an adverse effect on the ability of the Company to conduct its
business.  Furthermore, because patent applications in the United
States are maintained in secrecy until issue, and because
publication of discoveries in the scientific and patent
literature often lag behind actual discoveries, the Company
cannot be certain that it was the first chronologically to make
the inventions covered by each of its pending U.S. patent
applications, or that it was the first to file patent
applications for such inventions.  In the event that a third
party has also filed a U.S. patent application for any of its
inventions, the Company may have to participate in interference
proceedings declared by the United States Patent and Trademark
Office to determine priority of the invention, which could result
in substantial cost to the Company, even if the eventual outcome
is favorable to the Company.  In addition, there can be no
assurance that the Company's U.S. patents, including those of its
licensors, would be held valid by a court of law of competent
jurisdiction.  If patents are issued to other companies that
contain competitive or conflicting claims which ultimately may be
determined to be valid, there can be no assurance that the
Company would be able to obtain a license to any of these
patents.

Under Title 35 of the United States Code, as amended by the
General Agreement on Tariffs and Trade implementing the Uruguay
Round Agreement Act of 1994 ("GATT"), patents that issue from
patent applications filed prior to June 8, 1995 will enjoy a 17-
year period of enforceability as measured from the date of patent
issue while those that issue from applications filed on or after
June 8, 1995 will enjoy a 20-year period of enforceability as
measured from the date the patent application was filed or the
first claimed priority date, whichever is earlier. Patents that
issue from applications filed on or after June 8, 1995 may be
extended under the term extension provisions of GATT for a period
up to five years to compensate for any period of enforceability
lost due to interference proceedings, government secrecy orders
or appeals to the Board of Patent Appeals or the Federal Circuit.

Under the Drug Price Competition and Patent Term Restoration Act
of 1984, including amendments implemented under GATT (the "Patent
Term Restoration Act"), the period of enforceability of a first
or basic product patent or use patent covering a drug may be
extended for up to five years to compensate the patent holder for
the time required for FDA regulatory review of the product. This
law also establishes a period of time following FDA approval of
certain drug applications during which the FDA may not accept or
approve applications for similar or identical drugs from other
sponsors. Any extension under the Patent Term Restoration Act and
any extension under GATT are cumulative. There can be no
assurance that the Company will be able to take advantage of such
patent term extensions or marketing exclusivity provisions of
these laws. While the Company cannot predict the effect that such
changes will have on its business, the adoption of such changes
could have a material adverse effect on the Company's ability to
protect its proprietary information and sustain the commercial
viability of its products. Furthermore, the possibility of
shorter terms of patent protection, combined with the lengthy FDA
review process and possibility of extensive delays in such
process, could effectively further reduce the term during which a
marketed product could be protected by patents.

The Company also relies on trade secrets and proprietary
know-how.  The Company has been and will continue to be required
to disclose its trade secrets and proprietary know-how to
employees and consultants, potential corporate partners,
collaborators and contract manufacturers.  Although the Company
seeks to protect its trade secrets and proprietary know-how, in
part by entering into confidentiality agreements with such
persons, there can be no assurance that these agreements will not
be breached, that the Company would have adequate remedies for
any breach or that the Company's trade secrets will not otherwise
become known or be independently discovered by competitors.

Scientific Advisory and Clinical Trials Advisory Boards

Scientific Advisory Board

The Company currently has a Scientific Advisory Board ("SAB")
whose members periodically advise the Company with respect to the
Company's scientific research and development programs.  The SAB
does not meet as a group; rather, individual members are
contacted for advice on an as-needed basis. The members are
compensated through the grant of stock options and, if meetings
are held, will receive fees for attending meetings as well as
reimbursement for expenses. The Company has hired certain SAB
members to perform services for the Company such as assay
development and compound preparation.

The members of the Company's SAB are:

Name and Affiliation                         Area of Expertise

Chung Hsu, M.D., Ph.D.
Director of  Stroke Clinical Trials,
Washington University, St. Louis        Animal models of
School of Medicine                      stroke/clinical trials

Ronald Hayes, Ph.D.
Professor of Neurosurgery,              Animal models of head
University of Texas, Houston            trauma

Bruce P. Bean, Ph.D.
Professor of Neurobiology,
Harvard University                      Neuronal ion channels

Robert Parks, M.D., Ph.D.
Professor Emeritus of Pharmacology,
Brown University                        Biochemical pharmacology

John Olney, M.D.
Professor of Psychiatry and
Neuropathology,                              Excitotoxicity;
Washington University, St.  Louis       animal models of stroke

Edward J. Cragoe, Ph.D.
Former Senior Director of
Medicinal Chemistry,                    Medicinal chemistry/ion
Merck Sharp & Dohme Research Laboratories     channels

K.C.  Nicolaou, Ph.D.
Head of Chemistry,
The Scripps Research Institute
Professor of Chemistry,
University of California, San Diego     Medicinal chemistry

Harold Kimelberg, Ph.D.
Professor, Division of Neurology,       Glial cell release of
Albany Medical College                  glutamate

Elie Abushanab, Ph.D.                   Medicinal chemistry/
                                        adenosine

Thomas J. Maloney
President,
The Iso-Tex Companies,                  Radioisotopes/Nuclear
Friendswood, Texas                      Medicine

Claude Wasterlain, M..D.
Chief of Neurology Services,
Sepulveda VA Medical Center,
Professor of Neurology,
University of California Los Angeles   Stroke and epilepsy

Clinical Trials Advisory Boards

The Company has assembled two Clinical Trials Advisory Boards
("CTABs"), composed of physician "thought leaders" in the
cardiology and neurology area, to assist in the planning, design
and execution of the Company's clinical trials involving Cordox
and Ceresine.  The individuals who constitute each of the CTABs
are paid consultants to the Company and are listed below:

Cardiovascular Clinical Trials Advisory Board

Eric J. Topol, M.D. (Chair)
Chairman, Department of Cardiology,
Director, Center for Thrombosis and Vascular Biology,
Cleveland Clinic and Foundation

David R. Holmes, Jr., M.D.
Associate Professor of Medicine,
Mayo Clinic Medical School

Robert M. Califf, M.D.
Associate Professor of Medicine,
Duke University Medical Center

Cerebrovascular Clinical Trials Advisory Board

William G. Barsan, M.D. (Chair)
Director  of Emergency Medicine,
University of Michigan Medical School

Patrick M. Kochanek, M.D.
Safar Center for Resuscitation Research
University of Pittsburgh
Pittsburgh, Pennsylvania

Randall M. Chestnut, M.D.
Oregon Health Sciences Center
School of Medicine, Division of Neurosurgery
Portland, Oregon

Patrick D. Lyden, M.D.
Chief, Stroke Clinic
University of California, San Diego

Charles F. Contant, Jr., Ph.D.
Baylor College of Medicine
Department of Neurosurgery
Houston, Texas

Anthony Marmarou, Ph.D.
Medical College of Virginia
Division of Neurosurgery
Richmond, Virginia

The members of the SAB and the CTABs may be employed by or have
consulting agreements with entities other than the Company, some
of which may compete with the Company. These other obligations
may limit the availability of the members to the Company.  Most
are not expected to participate actively in the Company's
development.  Certain of the institutions with which the members
are affiliated may have regulations or policies which are unclear
with respect to the ability of such persons to act as part-time
consultants or in other capacities for a commercial enterprise.
Regulations or policies now in effect or adopted in the future
may limit the ability of the members to consult with the Company.
The loss of the services of certain of the members could
adversely affect the Company.

Furthermore, inventions or processes discovered by the SAB and
CTAB members will not, unless otherwise agreed, become the
property of the Company but will remain the property of such
persons or of their full-time employers.  In addition, the
institutions with which the members are primarily affiliated may
make available the research services of their scientific and
other skilled personnel, including the members, to entities other
than the Company.  In rendering such services, such institutions
may be obligated to assign or license to a competitor of the
Company patents and other proprietary information which may
result from such services, including research performed by a
member for a competitor of the Company.

Scientific and Other Personnel

As of  October 26, 1998, the Company had 42 full-time employees,
eight of whom hold Ph.D. degrees, two of whom also hold an M.D.
degree and one of whom holds a J.D. degree.  Twelve of the full-
time employees are employed in finance and general
administration, seven in clinical and regulatory affairs, eight
in quality control and quality assurance, four in pre-clinical
research and development, and eleven in sales and marketing,
customer service and business development.  The Company believes
that it maintains good relations with its employees.

Executive Officers of Registrant

Set forth below is certain information with respect to the
executive officers of the Company at October 26, 1998:

Name                    Age  Position

Paul J. Marangos,       51   Chairman of the Board, President
Ph.D.                        and Chief Executive Officer

Zofia E. Dziewanowska,  59   Senior Vice President, Drug
Ph.D, M.D.                   Development and Regulatory Affairs

David W. Nassif,        44   Senior Vice President, Chief Financial
J.D.                         Officer and Secretary

Larry A. Risen          36   Vice President of Corporate Development

Brian W. Sullivan       39   Vice President of Product Development

Paul J. Marangos, Ph.D., has been President and Chairman of the
Board since he founded the Company in November 1990.  In February
1993, he became Chief Executive Officer. From April 1988 to
November 1990, he was Senior Director of Research at Gensia
Pharmaceuticals, Inc., a biotechnology company.  From 1980 to
1988, he was Chief of Neurochemistry in the Biological Psychiatry
Branch, National Institute of Mental Health.  Dr.  Marangos
obtained his doctorate in biochemistry from the University of
Rhode Island and did his post-doctoral work at the Roche
Institute of Molecular Biology.  He has published 250 research
papers and four books in the field of biochemistry and
pharmacology, the most recent of which is entitled Emerging
Strategies in Neuroprotection.  He is a member of the Society for
Neuroscience and the American Academy for the Advancement of
Science.  Dr. Marangos is the founding editor of the Journal of
Molecular Neuroscience published by Humana Press.

Zofia E. Dziewanowska, Ph.D., M.D., joined the Company in October
1997 as the Senior Vice President of Drug Development and
Regulatory Affairs.  From May 1994 to October 1997, she was the
Senior Vice President, Global Clinical Affairs, of Genta
Incorporated ("Genta"), a publicly-traded pharmaceutical company
principally engaged in developing a proprietary drug delivery
technology to develop oral controlled-release  formulations.
Prior to joining Genta, Dr. Dziewanowska spent 17 years at
Hoffman-La Roche in various research and development positions,
including Vice President and Director of International
Therapeutic Research and Medical Affairs Advisor. Dr.
Dziewanowska currently holds a faculty appointment at the Cornell
University Medical School. She also has held various positions in
the Pharmaceutical Research and Manufacturers Association of
America, the most recent being a Vice-Chairman of the Medical
Section Steering Committee, American Association of
Pharmaceutical Physicians and the International Federation of
Pharmaceutical Medicine. Dr. Dziewanowska received an M.D. degree
from the University of Warsaw Medical School and a Ph.D. in
physiology from the Institute of Immunology and Experimental
Therapeutics, Polish Academy of Science.

David W. Nassif, J.D., joined the Company in August 1993 as Vice
President, Chief Financial Officer and Secretary, and was
promoted to Senior Vice President in September 1997.  From
January 1993 to August 1993, he was a consultant to various
public and private companies in the areas of capital raising,
mergers and acquisitions, investor relations and securities law
compliance.  From July 1992 to January 1993, he was the Vice
President, Chief Financial Officer and Assistant Secretary of
999, Inc., a diversified manufacturing and environmental services
company. From December 1987 to July 1992, he was the Vice
President and Assistant Secretary of Showscan Corporation, a
technology company.  Mr. Nassif holds honors finance, management
information systems and law degrees from the University of
Virginia.

Larry A. Risen joined the Company in November 1994 as Associate
Director of Business Development, was promoted to Director of
Business Development in August 1995 and to Vice President of
Corporate Development in September 1998. From August 1990 to
November 1994, Mr. Risen was employed at Gen-Probe, Inc., a
developer, manufacturer and marketer of diagnostic tests; first
as Product Manager from August 1990 to November 1993 and as
Marketing Manager from November 1993 to November 1994. Mr. Risen
holds a B.Sc. degree in Biology from the University of Iowa.

Brian W. Sullivan, Ph.D., joined the Company in April 1994 as
Associate Director, Chemistry, was promoted to Director of
Pharmaceutical Chemistry in November 1995 and  to Vice President
of Product Development in September 1998. From 1985 to April
1994, Dr. Sullivan was employed at Hybritech, Inc., a developer,
manufacturer and marketer of in vitro diagnostic products;  first
as Research Scientist from 1985 to 1991 and then as a Scientific
Investigator from 1991 to 1994. Dr. Sullivan holds a B.A. in
Chemistry and a Ph.D. in Marine Natural Products Chemistry from
the University of California, San Diego.

Item 2. Properties.

The Company leases two buildings in Carlsbad, California at a
total monthly rental of $37,651. All of the Company's operations
are located in 18,339 square feet of space located at 2714 Loker
Avenue West (the "2714 Space"). In April 1997, the Company
subleased its other building at 2732 Loker Avenue West (the "2732
Space") to another pharmaceutical company (the "Subtenant").
     
The Company has leases on two floors in the 2714 Space, one of
which commenced in April 1996 and has a term of 69 months, and
the other of which commenced in November 1996 and has a term of
61 months. The lease on the 2732 Space commenced in December 1993
and has a term of 81 months. Both leases have clauses providing
for rent increases at various points in time during the terms of
the leases. The Subtenant's lease covers the remainder of the
Company's original lease term plus a 36-month option, and the
Subtenant's rental payments to the Company exceed the Company's
rental payments to the landlord. In addition, the sublease
provides for annual rent increases. Under the sublease, the
Company spent approximately $200,000 on tenant improvements (the
"Tenant Improvement Obligation") to the 2732 Space, however, the
net present value of the Subtenant's rental payments over the
term of the sublease greatly exceeds the Tenant Improvement
Obligation.

Item 3. Legal Proceedings.

In July 1998, the Company was served with a complaint in the
United States Bankruptcy Court for the Southern District of New
York by the Trustee for the Liquidation of the Business of A.R.
Baron & Co., Inc. ("A.R. Baron") and the Trustee of The Baron
Group, Inc. (the "Baron Group"), the parent of A.R. Baron. The
complaint alleges that A.R. Baron and the Baron Group made
certain preferential or fraudulent transfers of funds to the
Company prior to the commencement of bankruptcy proceedings
involving A.R. Baron and the Baron Group. The Trustee is seeking
return of the funds, totalling $3.2 million. The Company believes
that the Trustee's claims are unfounded and intends to contest
the allegations in the complaint vigorously. The Company contends
that the transfers challenged by the Trustee relate to (i) the
exercise by A.R. Baron in 1995 of unit purchase options issued to
it in 1992 as part of its negotiated compensation for
underwriting the Company's initial public offering and (ii) the
repayment by the Baron Group of the principal and interest (at
12% per annum) payments and certain loan extension fees related
to certain collateralized loans made to it by the Company in 1995
and 1996. The Company believes that it has insurance coverage
sufficient to cover any costs, expenses or losses that might be
incurred in connection with this action.

Item 4. Submission of Matters to a Vote of Security Holders.

No matters were submitted to a vote of the Company's security
holders during the fourth quarter of the fiscal year ended July
31, 1998.

PART II.

Item 5. Market for Registrant's Common Equity and Related
Shareholder Matters.

The Common Stock of the Company was quoted on the Nasdaq National
Market System  under the symbol "CYPR" until January 1998. In
January 1998, the Company was listed on the American Stock
Exchange, Inc. under the symbol "CYP". The Redeemable Class B
Warrants of the Company were also quoted on the Nasdaq National
Market System under the symbol "CYPRZ" until November 3, 1997,
when they expired.
     
The following table sets forth for the calendar quarters
indicated, the high and low sales prices of the Common Stock on
the Nasdaq National Market System and the American Stock
Exchange, Inc., as reported in published financial sources, for
the periods that the Common Stock was quoted or listed.

Year ended July 31, High Low 1998 First Quarter $6.12 $3.75 Second Quarter $6.00 $3.81 Third Quarter $4.75 $3.50 Fourth Quarter $5.43 $3.37 Year ended July 31, High Low 1997 First Quarter $5.75 $3.48 Second Quarter $5.75 $3.63 Third Quarter $5.88 $4.00 Fourth Quarter $5.81 $4.00
The last sales price of the Common Stock on October 26, 1998 was $2.375. According to a survey of non-objecting beneficial owners as of August 23, 1998, there were 2,373 beneficial owners of the Common Stock. The Company has not paid any dividends since its inception and does not intend to pay any dividends on its Common Stock in the foreseeable future. Item 6. Selected Financial Data. The following table sets forth certain financial data with respect to the Company. The selected financial data should be read in conjunction with the Company's Financial Statements (including the Notes thereto) and "Management's Discussion and Analysis of Financial Condition and Results of Operations" appearing elsewhere in this Report.
Years Ended July 31, 1994 1995 1996 1997 1998 (in thousands, except per share data) Statement of Operations Data: Net sales $ - $ - $ 1,275 $ 2,428 $ 3,446 Gross profit - - 870 1,890 2,675 Total operating expenses 2,565 3,910 4,988 7,466 9,139 Loss from operations (2,565) (3,910) (4,118) (5,576) (6,464) Other income (expense), net 190 797 1,028 (1,099) 891 Net loss (2,375) (3,113) (3,090) (6,675) (5,573) Net loss per share - basic and diluted (0.32) (0.32) (0.27) (0.54) (0.37) Shares used in computing net loss per share - basic and diluted 7,358 9,860 11,518 12,303 15,187 At July 31, Balance Sheet Data: 1994 1995 1996 1997 1998 (in thousands) Cash, cash equivalents and short-term investments $ 5,666 $13,442 $15,997 $14,567 $13,444 Working capital 5,284 12,934 15,384 13,076 13,378 Total assets 6,206 14,175 20,266 21,345 19,736 Long-term debt 240 195 6,624 4,176 217 Common stock 9,927 20,945 23,421 32,345 41,328 Accumulated deficit (4,279) (7,392) (10,482) (17,157) (22,730) Total shareholders' equity 5,476 13,366 12,635 15,026 18,511
Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations Except for the historical information contained herein, the following discussion contains forward-looking statements that involve risks and uncertainties, including statements regarding the period of time during which the Company's existing capital resources and income from various sources will be adequate to satisfy its capital requirements. The Company's actual results could differ materially from those discussed herein. Factors that could cause or contribute to such differences include, but are not limited to, those discussed in this section, as well as in the sections entitled "Business", "Licenses", "Manufacturing", "Sales and Marketing", "Competition", "Government Regulation", "Patents and Proprietary Rights", those discussed in the S-3 Registration Statement File No. 333-25661 filed with U.S. Securities and Exchange Commission, as well as those discussed in any documents incorporated by reference herein or therein. The Company was founded in 1990, commenced its research and development activities in 1991, completed an initial public offering (the "IPO") in November 1992, commenced clinical trials in December 1994, acquired two FDA-cleared products, Glofil and Inulin, (the "Acquisitions") in August 1995, acquired a third FDA- cleared product, Ethamolin, in November 1996, and acquired the Dermaflo technology in November 1997. The Company has sustained an accumulated deficit of $22,730,000 from inception through July 31, 1998. As the Company will not have positive net operating cash flow for the next few years and the Company's research and development, clinical testing and regulatory, sales and marketing and general and administrative expenses during these years will be substantial and increasing, the Company expects to incur increasing losses for the foreseeable future. Results of Operations Year ended July 31, 1998 compared to year ended July 31, 1997 During the fiscal year ended July 31, 1998, the Company sustained a loss of $5,573,000 (or $.37 per share, basic and diluted) compared to a loss of $6,675,000 (or $.54 per share, basic and diluted) for the prior fiscal year. Gross profit for 1998 of $2,676,000 on sales of Glofil, Inulin and Ethamolin, plus other income of $1,150,000 (interest, grant, and rental income) were offset by $9,139,000 in expenses for sales and marketing, general and administrative, clinical testing and regulatory, pre-clinical research and development and depreciation and amortization and $259,000 in amortization of discount and costs on its mandatorily convertible notes (the "Notes"). During the prior fiscal year, the gross profit of $1,890,000 on sales of Glofil and Inulin and other income of $761,000 (principally interest income) was offset by $7,465,000 in expenses for sales and marketing, general and administrative, clinical testing and regulatory, and pre-clinical research and development as well as depreciation and amortization. During the third quarter, the Company announced that its largest Glofil customer had informed the Company that it would be terminating two clinical trials which require Glofil to be used as part of their protocols. Those trials have terminated and as stated previously in the third quarter, the Company expects the loss of sales to this customer to slow the rate of overall sales growth for the next six to nine months. Sales and marketing expense increased by 31.8% to $1,310,000 from $994,000 in the prior year, principally as a result of additional promotional costs for Glofil and increased payroll expense from pay raises and the hiring of additional personnel. General and administrative expense increased by 35.5% to $3,247,000 from $2,396,000 in the prior year. Approximately 52% of the increase was due to the expenditures related to acquiring the Dermaflo technology and scaling up the manufacturing of the Dermaflo products. Sometime during the fiscal year ending July 31, 1999, the Company expects to have at least one Dermaflo product available for sale at which point most of the ongoing Dermaflo expense will be accounted for as cost of sales and the Company's gross profit margin on both an absolute and percentage basis will suffer until sales of the Dermaflo products reach a certain level. The remainder of the increase reflected increased legal fees. Clinical testing and regulatory expense increased by 28.2% to $2,521,000 from $1,967,000 in the prior year, principally as the result of increased staffing in the quality assurance/quality control department, increased use of data input and management, statistical and other consultants to accelerate, finish and report on the Company's various clinical trials and certain toxicology studies performed during the period. Pre-clinical research and development expense decreased by 20.4% to $822,000 from $1,032,000 in the prior year, principally due to a decrease in staffing and the completion of certain contract studies. Depreciation and amortization expense increased by 15.3% to $1,239,000 from $1,075,000 in the prior year, principally as a result of the acquisition of Ethamolin during the prior year and the related amortization of that purchased technology. Sublease income increased 100% to $171,062 in the current year due to the sublease of the Company's former corporate headquarters. Interest and other income increased by 22.2% to $809,000 from $662,000 in the prior year, principally due to the additional interest earned on the proceeds from the exercise of the Company's Redeemable Class B Warrants in November 1997. Research and grant income increased 71.7% to 170,000 from 99,000 in the prior year, principally due to the receipt of two additional Small Business Innovation Research grants during the current year versus the receipt of one in the prior year. The amortization of discount and costs on the Notes decreased 86.1% to $259,000 from $1,860,000 in the prior year. The majority of the principal amount of the Notes was converted in the prior year, and thus, a larger amount of amortization expense occurred. The remaining principal balance of the Notes was converted in the current year. Year ended July 31, 1997 compared to year ended July 31, 1996 During the fiscal year ended July 31, 1997, the Company sustained a loss of $6,675,000 (or $.54 per share, basic and diluted) compared to a loss of $3,090,000 (or $.27 per share, basic and diluted) for the prior fiscal year. The gross profit of $1,890,000 on sales of Glofil, Inulin and Ethamolin and other income of $761,000 (principally interest income) during the 1997 fiscal year were offset by $7,465,000 in expenses for sales and marketing, general and administrative, clinical testing and regulatory, pre-clinical research and development and depreciation and amortization and $1,860,000 in amortization of discount and costs on the Notes. During the 1996 fiscal year, the gross profit of $870,000 on sales of Glofil and Inulin and other income of $1,028,000 (principally interest income) was offset by $4,988,000 in expenses for sales and marketing, general and administrative, clinical testing and regulatory, pre-clinical research and development and depreciation and amortization. Sales and marketing expense increased by 190% to $994,000 in fiscal 1997 from $343,000 in fiscal 1996, principally as a result of increased payroll expense from the hiring of additional field sales representatives, a product manager and an administrative assistant, and related travel, hotel and meal costs. General and administrative expense increased by 46% to $2,396,000 in fiscal 1997 from $1,642,000 in fiscal 1996. Approximately 38% of the increase was due to the commencement of a comprehensive investor relations program and the remainder reflected the impact of the expansion of the Company's activities on personnel, consulting, business development, investment banking, rent, travel and meals, legal and accounting fees and insurance. Clinical testing and regulatory expense increased 41.7% to $1,967,000 in fiscal 1997 from $1,389,000 in fiscal 1996, principally as the result of increased site costs and use of data input and management, statistical and other consultants to accelerate, finish and report on the Company's various clinical trials. Depreciation and amortization expense increased 75.6% to $1,075,000 from $612,000 in the prior year, principally as a result of the acquisition of Ethamolin during the 1997 fiscal year and the related amortization of that purchased technology. During the 1997 fiscal year, the Company recognized $1,860,000 of expense related to the amortization of (i) the discount on the Notes and (ii) the deferred financing costs related to the private placements of the Notes. This resulted from the re- classification of the Notes from equity to debt resulting from a review of the Company's various filings under the Securities Exchange Act of 1934 by the Securities and Exchange Commission triggered by the filing of a registration statement during the year pertaining to the resale of the Common Stock underlying some of the Notes. Liquidity and Capital Resources The Company has principally funded its activities to date through various issuances of equity securities, which have raised total net proceeds of $35.0 million, as well as product sales. At July 31, 1998, the Company had cash, cash equivalents and short-term investments of $13,444,000 compared to $14,567,000, at July 31, 1997. At July 31, 1998, working capital was $13,378,000, compared to $13,076,000 at July 31, 1997. The increase in both balance sheet items was principally due to the receipt of net proceeds of $4,708,000 from the exercise of 856,026 the Company's Redeemable Class B Warrants prior to their expiration in November 1997, offsetting the Company's cash spent on operations for the year. The Company expects that its cash needs will increase significantly in future periods due to expansion of its research and development programs, increased clinical testing activity, growth of administrative, clinical and laboratory staff and their related equipment and space needs. Management believes that the Company's working capital will be sufficient to fund the operations of the Company for approximately 24 months dependent, in part, on the timing of the commencement of each phase of the clinical trials on Cordox and Ceresine and the funding priorities that it gives its various research programs, the results of clinical tests and research programs; competing technological and market developments; the time and costs involved in obtaining regulatory approvals and in obtaining, maintaining and enforcing patents; the cost of product acquisitions and their resulting cash flows and other factors. The Company expects to seek additional funds through exercises of its currently outstanding options, public or private equity financings, collaborations or from other sources. There can be no assurance that funds can be obtained on desirable terms or at all. The Company may seek to raise additional capital whenever conditions in the financial markets are favorable, even if the Company does not have an immediate need for additional cash at that time. Impact of the Year 2000 Issue The Year 2000 problem is the result of computer applications being written using two digits rather than four digits to define the applicable year. Any of the Company's computer applications (and computer applications used by any of the Company's customers, collaborators and manufacturers) that have time- sensitive software may recognize a date using "00" as the year 1900 rather than the year 2000. This could result in system failures or miscalculations causing disruption of operations. The Company has modified or replaced portions of its software so that its computer systems will function properly with respect to dates in the year 2000 and thereafter. The costs associated with such modifications were not materially significant. The Company believes that, with these modifications to existing software and conversions to new software, the Year 2000 problem will not pose significant operational problems for its computer systems. However, because of the many uncertainties associated with Year 2000 compliance issues, and because the Company's assessment is necessarily based on information from third-party customers, collaborators and manufacturers, there can be no assurance that the Company's assessment is correct or as to the materiality or effect of any failure of such assessment to be correct. The Company has initiated a program to determne whether the computer applications of its significant customers, collaborators and manufacturers will be upgraded in a timely manner. The Company has not completed its review and it is unknown whether the computer applications of its customers, collaborators and manufacturers will be Year 2000 compliant. The Company has not determined the extent to which any disruption in the computer applications of third parties caused by the Year 2000 issues will affect the Company's operations. However, any disruptions in payments by customers or in the manufacture of the Company's products could have a material adverse effect upon the Company's business, financial condition and results of operations. Item 7A. Quantitative and Qualitative Disclosure About Market Risk. The Company invests its excess cash in interest-bearing investment-grade securities. The Company holds all such securities for the remaining term of the security. Therefore, the Company believes that it is not subject to material interest rate risks on such investments, other than the creditworthiness of the issuer of such securities. In addition, the Company does not utilize market risk sensitive instruments, positions or transactions in any material fashion and does not believe it maintains any material exposure to such market risk sensitivities. Item 8. Financial Statements and Supplementary Data. The Financial Statements of the Company and Report of Ernst & Young LLP, Independent Auditors are filed as exhibits hereto, listed under Item 14 of this Report and incorporated herein by reference. Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure. None. PART III. Item 10. Directors and Executive Officers of the Registrant. The information regarding directors is hereby incorporated by reference to the section entitled "Election of Directors" in the Company's definitive Proxy Statement to be filed with the Securities and Exchange Commission in connection with the Company's 1999 Annual Meeting of Shareholders (the "Proxy Statement"). The information regarding executive officers appears under the section entitled "Executive Officers of Registrant" appearing in Item 1 of Part I of this Report. Item 11. Executive Compensation. The information required by this item is hereby incorporated by reference to the section entitled "Executive Compensation" in the Proxy Statement. Item 12. Security Ownership of Certain Beneficial Owners and Management. The information required by this item is hereby incorporated by reference to the section entitled "Security Ownership of Certain Beneficial Owners and Management" in the Proxy Statement. Item 13. Certain Relationships and Related Transactions. The information required by this item is hereby incorporated by reference to the section entitled "Transactions with Related Parties" in the Proxy Statement. Item 14. Exhibits, Financial Statement Schedules and Reports on Form 8-K. (a) (1)(2) Financial Statements and Schedules. The financial statements are incorporated herein by reference from Exhibit 99.1, which begins with the Table of Contents on Page F- 1. (a) (3) Exhibits. See Exhibit Index on page 32. The following management compensation plans and arrangements are required to be filed as exhibits pursuant to Item 14(c) of this report. Exhibit Number Description 10.1 Forms of Incentive Stock Option and Nonstatutory Stock Option.* 10.2 Amended 1992 Stock Option Plan. 10.3 Employment Agreement, dated July 10, 1991 as amended and restated September 1, 1992, between the Registrant and Paul J. Marangos, Ph.D. * 10.4 Amendment No. 1 to Employment Agreement, dated May 9, 1994, between the Registrant and Paul J. Marangos, Ph.D.** 10.5 Amendment No. 2 to Employment Agreement, dated March 9, 1995, between the Registrant and Paul J. Marangos, Ph.D.*** 10.6 Amendment No. 3 to Employment Agreement, dated October 1, 1996, between the Registrant and Paul J. Marangos, Ph.D.**** 10.7 Employment Agreement dated December 6, 1997 between the Registrant and Zofia E. Dziewanowska, M.D., Ph.D.***** 10.8 1993 Non-Employee Directors Stock Option Plan and related form of Nonstatutory Stock Option. ****** ____________ * Filed as an exhibit to the Registrant's Registration Statement on Form S-1, Registration No. 33-51682, and incorporated herein by reference. ** Filed as an exhibit to the Registrant's Form 10-K for the fiscal year ended July 31, 1994. *** Filed as an exhibit to the Registrant's Form 10-K for the fiscal year ended July 31, 1995. **** Filed as an exhibit to the Registrant's Form 10-K for the fiscal year ended July 31, 1996. ***** Filed as an exhibit to the Registrant's Form 10-Q for the period ended October 31, 1997. ****** Filed as an exhibit to the Registrant's Form 10-K for the fiscal year ended July 31, 1993. (b) Reports on Form 8-K. There were no reports on Form 8-K filed during the fourth quarter of 1998. (c) Exhibits. The exhibits required by this Item are listed under Item 14 (a) (3). (d) Financial Statement Schedules. No financial statement schedules are required. SIGNATURES Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized, in the City and County of San Diego, State of California, on the 26th day of October, 1998. CYPROS PHARMACEUTICAL CORPORATION By /s/ Paul J. Marangos - ----------------------- Paul J. Marangos Chairman of the Board, President and Chief Executive Officer POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Paul J. Marangos, and David W. Nassif, and each of them, his attorney-in-fact, each with the power of substitution, for him in any and all capacities, to sign any amendments to this report, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his substitute or substitutes, may do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the Registrant and in the capacities and on the dates indicated.
Signature Title Date /s/ Paul J. Marangos Chairman of the October 26, 1998 - -------------------- Board, President and Paul J. Marangos Chief Executive Officer and Director (Principal Executive Officer) /s/ David W. Nassif Senior Vice October 26, 1998 - -------------------- President, Chief David W. Nassif Financial Officer and Secretary (Principal Financial and Accounting Officer) /s/Robert F. Allnutt Director October 26, 1998 - -------------------- Robert F. Allnutt /s/ Digby W. Barrios Director October 26, 1998 - -------------------- Digby W. Barrios /s/ Virgil Thompson Director October 26, 1998 - -------------------- Virgil Thompson /s/Robert A.Vukovich Director October 26, 1998 - -------------------- Robert A. Vukovich
Exhibit Index Exhibit Number Description 2.1 (1) Pharmaceutical Products Purchase and Distribution Support Agreement as of August 9, 1995 by and among Iso-Tex Diagnostics, Inc., Cypros Pharmaceutical Corporation and Thomas J. Maloney. (2) 2.2 (1) Glofil Contract Manufacturing and Royalty Agreement as of August 9, 1995 by and among Iso-Tex Diagnostics, Inc., Cypros Pharmaceutical Corporation and Thomas J. Maloney. (2) 2.3 (1) Merger Agreement as of August 9, 1995 among Cypros Pharmaceutical Corporation, Iso-Tex Diagnostics "B", Inc. and Jean and Thomas Maloney. (2) 2.4 (3) Asset Purchase Agreement by and among Cypros Pharmaceutical Corporation and Schwarz Pharma, Inc. dated as of October 31, 1996 2.5 (3) Note and Security Agreement by and among Cypros Pharmaceutical Corporation and Schwarz Pharma, Inc. dated November 4, 1996 2.6 (3) Assumption Agreement by and among Schwarz Pharma, Inc. and Cypros Pharmaceutical Corporation dated November 4, 1996 2.7 (3) Trademark Assignment by and among Schwarz Pharma, Inc. and Cypros Pharmaceutical Corporation dated November 4, 1996 2.8 (3) Trademark Agreement by and among Schwarz Pharma, Inc. and Cypros Pharmaceutical Corporation dated November 4, 1996 3.1 (4) Restated Articles of Incorporation of the Registrant. 3.2 (5) Amendment to Restated Articles of Incorporation. 3.3 (4) Bylaws. 3.4 Certificate of Adoption of Bylaw Amendment. 4.1 (4) Specimen stock certificate. 4.2 Reference is made to Exhibits 3.1 and 3.2. 10.1 (4) Forms of Incentive Stock Option and Nonstatutory Stock Option. 10.2 Amended 1992 Stock Option Plan. 10.3 (4) Employment Agreement, dated July 10, 1991 as amended and restated September 1, 1992, between the Registrant and Paul J. Marangos, Ph.D. 10.4 (6) Amendment No. 1 to Employment Agreement, dated May 9, 1994, between the Registrant and Paul J. Marangos, Ph.D. 10.5 (7) Amendment No. 2 to Employment Agreement, dated March 9, 1995, between the Registrant and Paul J. Marangos, Ph.D. 10.6 (8) Amendment No. 3 to Employment Agreement, dated October 1, 1996, between the Registrant and Paul J. Marangos, Ph.D. 10.7 (9) 1993 Non-Employee Directors Stock Option Plan and related form of Nonstatutory Stock Option. 10.8 (4) License Agreement, dated as of August 20, 1992, between the Registrant and Angel K. Markov, M.D. (with certain confidential information in brackets deleted). (8) Exhibit Number Description 10.9 (4) License Agreement, dated as of August 27, 1992, between the Registrant and University E..M., Inc. (with certain confidential information in brackets deleted). (9) 10.10 (5) Assignment of and Amendment to License Agreement by and between University E.M., Inc., University of Cincinnati and the Registrant. 10.11 (7) License and Support Agreement, dated as of February 18, 1993, between the Registrant and Elie Abushanab, Ph.D. (with certain confidential information in brackets deleted). (10) 10.12 (12) Employment Agreement dated December 6, 1997 between the Registrant and Zofia E. Dziewanowska, M.D., Ph.D. 23.1 Consent of Ernst & Young LLP, Independent Auditors. 24.1 Power of Attorney. Reference is made to page 31. 27 Financial Data Schedule. (Exhibit 27 is submitted as an exhibit only in the electronic format of this Annual Report on Form 10-K submitted to the Securities and Exchange Commission.) 99.1 Financial Statements. __________ (1) Filed as an exhibit to the Registrant's Form 8-K dated August 10, 1995 and incorporated herein by reference. (2) Certain confidential portions deleted pursuant to an application for Order Granting Confidential Treatment Under the Securities Exchange Act of 1934 and Rule 24b-2 Thereunder filed concurrently with the Form 8-K. (3) Filed as an exhibit to the Registrant's Form 8-K dated November 4, 1996 and incorporated herein by reference. (4) Filed as an exhibit to the Registrant's Registration Statement on Form S-1, Registration No. 33-51682, and incorporated herein by reference. (5) Filed as an exhibit to the Registrant's Form 10-Q for the period ended January 31, 1995, and incorporated herein by reference. (6) Filed as an exhibit to the Registrant's Form 10-K for the fiscal year ended July 31, 1994. (7) Filed as an exhibit to the Registrant's Form 10-K for the fiscal year ended July 31, 1993. (8) Filed as an exhibit to the Registrant's Form 10-K for the fiscal year ended July 31, 1996. (9) Certain confidential portions deleted pursuant to Order Granting Application Under the Securities Act of 1933 and Rule 406 Thereunder Respecting Confidential Treatment, dated November 3, 1992. (10) Certain confidential portions deleted pursuant to Order Granting Application Pursuant to Rule 24B-2 Under the Securities Exchange Act of 1934 Respecting Confidential Treatment, dated December 20, 1993. (11) Filed as an exhibit to the Registrant's Form 8-K dated September 20, 1996 and incorporated herein by reference. (12) Filed as an exhibit to the Registrant's Form 10-Q for the period ended October 31, 1997.
CYPROS PHARMACEUTICAL CORPORATION                 EXHIBIT 3.4
CERTIFICATE OF ADOPTION OF
BYLAW AMENDMENT

David W. Nassif certifies that:

1.   He is a Vice President and Secretary of Cypros
Pharmaceutical Corporation (the"Corporation"), a California
corporation.

2.   In his above capacity as Secretary he has access to the
corporate records of said Corporation;

3.   The following resolution was duly moved, seconded and
adopted by a unanimous written consent of the Board of Directors
of the Corporation dated November 6, 1995, and that subsequently
the following resolution was duly moved, seconded and
adopted by a majority of the 11,404,373 outstanding shares of
Common Stock of the Corporation entitled to vote at its Annual
Meeting of Shareholders held at the executive offices of the
Corporation on January 22, 1996 (the "Annual Meeting") in
accordance with Section 903 (a) (1) of the General Corporation
Law of the State of California;

RESOLVED, that Article III, Section 2 of the Bylaws of the
Company, as amended, is amended to read in its entirety as
follows:

"Section 2.  -   Number and Qualification of Directors.The
number of directors of the Corporation shall be not less
than four (4) nor more than (7). The exact number of
directors shall be five (5) until changed, within the limits
specified above, by a bylaw amending this Section 2, duly
adopted by the board of directors or by the shareholders.
The indefinite number of directors may be changed, or a
definite number fixed without provision for an indefinite
number, by a duly adopted amendment to the articles of
incorporation or by an amendment to this bylaw duly adopted
by the vote or written consent of holders of a majority of
the outstanding shares entitled to vote. No amendment may
change the stated maximum number of authorized directors to
a number greater than two (2) times the stated minimum
number of directors minus (1)."

I further declare under  penalty of perjury under the laws of the
State of California that the matters set forth in this
certificate are true and correct of my own knowledge.

IN WITNESS WHEREOF, I have hereunto set my hand this 7th day of
February, 1996.

/s/ David W. Nassif
- --------------------
David W. Nassif
Vice President and Secretary


EXHIBIT 10.2



CYPROS PHARMACEUTICAL CORPORATION
1992 STOCK OPTION PLAN
Adopted by the Board of Directors and Shareholders on August 20,
1992
Amended by the Committee on August 31, 1993
Amended by the Committee on November 15, 1993
Amended by the Committee on November 4, 1994
Amended by the Committee and the Board of Directors on November 14, 1997

1.   PURPOSES.

(a)  The purpose of the Plan is to provide a means by which
selected Employees and Directors of and Consultants to the
Company, and its Affiliates, may be given an opportunity to
purchase stock of the Company.

(b)  The Company, by means of the Plan, seeks to retain the
services of persons who are now Employees or Directors of or
Consultants to the Company, to secure and retain the services of
new Employees, Directors and Consultants, and to provide
incentives for such persons to exert maximum efforts for the
success of the Company.

(c)  The Company intends that the Options issued under the Plan
shall, in the discretion of the Board or any Committee to which
responsibility for administration of the Plan has been delegated
pursuant to subsection 3(c), be either Incentive Stock Options or
Nonstatutory Stock Options.  All Options shall be separately
designated Incentive Stock Options or Nonstatutory Stock Options
at the time of grant, and in such form as issued pursuant to
section 6, and a separate certificate or certificates will be
issued for shares purchased on exercise of each type of Option.

2.   DEFINITIONS.

(a)  "Affiliate" means any parent corporation or subsidiary
corporation, whether now or hereafter existing, as those terms
are defined in Sections 424(e) and (f) respectively, of the Code.

(b)  "Board" means the Board of Directors of the Company.

(c)  "Code" means the Internal Revenue Code of 1986, as amended.

(d)  "Committee" means a Committee appointed by the Board in
accordance with subsection 3(c) of the Plan.

(e)  "Company" means Cypros Pharmaceutical Corporation, a
California corporation.

(f)  "Consultant" means any person, including an advisor, engaged
by the Company or an Affiliate to render services and who is
compensated for such services, provided that the term
"Consultant" shall not include Directors who are paid only a
director's fee by the Company or who are not compensated by the
Company for their services as Directors.

(g)  "Continuous Status as an Employee, Director or Consultant"
means the employment or relationship as a Director or Consultant
is not interrupted or terminated by the Company or any Affiliate.
The Board, in its sole discretion, may determine whether
Continuous Status as an Employee, Director or Consultant shall be
considered interrupted in the case of:  (i) any leave of absence
approved by the Board, including sick leave, military leave, or
any other personal leave; provided, however, that for purposes of
Incentive Stock Options, any such leave may not exceed ninety
(90) days, unless reemployment upon the expiration of such leave
is guaranteed by contract (including certain Company policies) or
statute; or (ii) transfers between locations of the Company or
between the Company, Affiliates or its successor.

(h)  "Director" means a member of the Board.

(i)  "Disability" means total and permanent disability as defined
in Section 22(e)(3) of the Code.

(j)  "Employee" means any person, including Officers and
Directors, employed by the Company or any Affiliate of the
Company.  Neither service as a Director nor payment of a
director's fee by the Company shall be sufficient to constitute
"employment" by the Company.

(k)  "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

(l)  "Non-Employee Director" means a Director who either (i) is
not a current Employee or Officer of the Company or its parent or
subsidiary, does not receive compensation (directly or
indirectly) from the Company or its parent or subsidiary for
services rendered as a consultant or in any capacity other than
as a Director (except for an amount as to which disclosure would
not be required under Item 404(a) of Regulation S-K promulgated
pursuant to the Securities Act ("Regulation S-K")), does not
possess an interest in any other transaction as to which
disclosure would be required under Item 404(a) of Regulation S-K,
and is not engaged in a business relationship as to which
disclosure would be required under Item 404(b) of Regulation S-K;
or (ii) is otherwise considered a "non-employee" for purposes of
Rule 16b-3.

(m)  "Incentive Stock Option" means an Option intended to qualify
as an incentive stock option within the meaning of Section 422 of
the Code and the regulations promulgated thereunder.

(n)  "Nonstatutory Stock Option" means an Option not intended to
qualify as an Incentive Stock Option.

(o)  "Officer" means a person who is an officer of the Company
within the meaning of Section 16 of the Exchange Act and the
rules and regulations promulgated thereunder.

(p)  "Option" means a stock option granted pursuant to the Plan.

(q)  "Option Agreement" means a written agreement between the
Company and an Optionee evidencing the terms and conditions of an
individual Option grant.  The Option Agreement is subject to the
terms and conditions of the Plan.

(r)  "Optioned Stock" means the common stock of the Company
subject to an Option.

(s)  "Optionee" means an Employee, Director or Consultant who
holds an outstanding Option.

(t)  "Outside Director" means a Director who is considered an
"outside director" for purposes of Section 162(m) of the Code.

(u)  "Plan" means this 1992 Stock Option Plan.

(v)  "Rule 16b-3" means Rule 16b-3 of the Exchange Act or any
successor to Rule 16b-3, as in effect with respect to the Company
when discretion is being exercised with respect to the Plan.

3.   ADMINISTRATION

(a)  The Plan shall be administered by the Board unless and until
the Board delegates administration to a Committee, as provided in
subsection 3(c).

(b)  The Board shall have the power, subject to, and within the
limitations of, the express provisions of the Plan:

(i)  To determine from time to time which of the persons eligible
under the Plan shall be granted Options; when and how the Option
shall be granted; whether the Option will be an Incentive Stock
Option or a Nonstatutory Stock Option; the provisions of each
Option granted (which need not be identical), including the time
or times such Option may be exercised in whole or in part; and
the number of shares for which an Option shall be granted to each
such person.

(ii) To construe and interpret the Plan and Options granted under
it, and to establish, amend and revoke rules and regulations for
its administration.  The Board, in the exercise of this power,
may correct any defect, omission or inconsistency in the Plan or
in any Option Agreement, in a manner and to the extent it shall
deem necessary or expedient to make the Plan fully effective.

(iii)     To amend the Plan as provided in Section 11.

(c)  The Board may delegate administration of the Plan to a
committee composed of not fewer than two (2) members (the
"Committee"), all of the members of which Committee may be, in
the discretion of the Board, Non-Employee Directors.  If
administration is delegated to a Committee, the Committee shall
have, in connection with the administration of the Plan, the
powers theretofore possessed by the Board (and references in this
Plan to the Board shall thereafter be to the Committee), subject,
however, to such resolutions, not inconsistent with the
provisions of the Plan, as may be adopted from time to time by
the Board.  The Board may abolish the Committee at any time and
revest in the Board the administration of the Plan.
Notwithstanding anything in this Section 3 to the contrary, at
any time, the Board or the Committee may delegate to a committee
of one or more members of the Board the authority to grant
Options to eligible persons who are not then subject to Section
16 of the Exchange Act.

4.   SHARES SUBJECT TO THE PLAN.

(a)  Subject to the provisions of Section 10 relating to
adjustments upon changes in stock, the stock that may be sold
pursuant to Options shall not exceed in the aggregate two million
seven hundred sixty-six thousand two hundred and eighty-eight
(2,766,288) shares of the Company's common stock.  If any Option
shall for any reason expire or otherwise terminate without having
been exercised in full, the stock not purchased under such Option
shall again become available for the Plan.

(b)  The stock subject to the Plan may be unissued shares or
reacquired shares, bought on the market or otherwise.

     5.   ELIGIBILITY.

(a)  Incentive Stock Options may be granted only to Employees.
Nonstatutory Stock Options may be granted only to Employees,
Directors or Consultants.

(b)  No person shall be eligible for the grant of an Option if,
at the time of grant, such person owns (or is deemed to own
pursuant to Section 424(d) of the Code) stock possessing more
than ten percent (10%) of the total combined voting power of all
classes of stock of the Company or of any of its Affiliates
unless the exercise price of such Option is at least one hundred
ten percent (110%) of the fair market value of such stock at the
date of grant and the Option is not exercisable after the
expiration of five (5) years from the date of grant.

(c)  In any calendar year, no Employee shall be eligible to be
granted Options covering an aggregate number of shares greater
than one hundred thousand (100,000) shares.

6.   OPTION PROVISIONS.

Each Option shall be in such form and shall contain such terms
and conditions as the Board shall deem appropriate.  The
provisions of separate Options need not be identical, but each
Option shall include (through incorporation of provisions hereof
by reference in the Option or otherwise) the substance of each of
the following provisions:

(a)  Term.  No Option shall be exercisable after the expiration
of ten (10) years from the date it was granted.

(b)  Price.  The exercise price of each Incentive Stock Option
shall be not less than one hundred percent (100%) of the fair
market value of the stock subject to the Option on the date the
Option is granted.  The exercise price of each Nonstatutory Stock
Option shall be not less than eighty-five percent (85%) of the
fair market value of the stock subject to the Option on the date
the Option is granted.

(c)  Consideration.  The purchase price of stock acquired
pursuant to an Option shall be paid, to the extent permitted by
applicable statutes and regulations, either (i) in cash at the
time the Option is exercised, or (ii) at the discretion of the
Board or the Committee, either at the time of the grant or
exercise of the Option, (A) by delivery to the Company of other
common stock of the Company, (B) according to a deferred payment
arrangement or other arrangement (which may include, without
limiting the generality of the foregoing, the use of other common
stock of the Company) with the person to whom the Option is
granted or to whom the Option is transferred pursuant to
subsection 6(d), or (C) in any other form of legal consideration
that may be acceptable to the Board.

In the case of any deferred payment arrangement, interest shall
be payable at least annually and shall be charged at the minimum
rate of interest necessary to avoid the treatment as interest,
under any applicable provisions of the Code, of any amounts other
than amounts stated to be interest under the deferred payment
arrangement.

(d)  Transferability.  An Incentive Stock Option shall not be
transferable except by will or by the laws of descent and
distribution, and shall be exercisable during the lifetime of the
person to whom the Option is granted only by such person.  A
Nonstatutory Stock Option shall only be transferable by the
Optionee upon such terms and conditions as are set forth in the
option agreement for such Nonstatutory Stock Option, as the Board
or the Committee shall determine in its discretion.

(e)  Vesting.  The total number of shares of stock subject to an
Option may, but need not, be allotted in periodic installments
(which may, but need not, be equal).  The Option Agreement may
provide that from time to time during each of such installment
periods, the Option may become exercisable ("vest") with respect
to some or all of the shares allotted to that period, and may be
exercised with respect to some or all of the shares allotted to
such period and/or any prior period as to which the Option became
vested but was not fully exercised.  During the remainder of the
term of the Option (if its term extends beyond the end of the
installment periods), the Option may be exercised from time to
time with respect to any shares then remaining subject to the
Option.  The Option may be subject to such other terms and
conditions on the time or times when it may be exercised (which
may be based on performance or other criteria) as the Board may
deem appropriate.  The vesting provisions of individual Options
may vary but in each case will provide for vesting of at least
twenty percent (20%) of the total number of shares subject to the
Option per year.  The provisions of this subsection 6(e) are
subject to any Option provisions governing the minimum number of
shares as to which an Option may be exercised.

(f)  Securities Law Compliance.  The Company may require any
Optionee, or any person to whom an Option is transferred under
subsection 6(d), as a condition of exercising any such Option,
(1) to give written assurances satisfactory to the Company as to
the Optionee's knowledge and experience in financial and business
matters and/or to employ a purchaser representative reasonably
satisfactory to the Company who is knowledgeable and experienced
in financial and business matters, and that he or she is capable
of evaluating, alone or together with the purchaser
representative, the merits and risks of exercising the Option;
and (2) to give written assurances satisfactory to the Company
stating that such person is acquiring the stock subject to the
Option for such person's own account and not with any present
intention of selling or otherwise distributing the stock.  These
requirements, and any assurances given pursuant to such
requirements, shall be inoperative if (i) the issuance of the
shares upon the exercise of the Option has been registered under
a then currently effective registration statement under the
Securities Act of 1933, as amended (the "Securities Act"), or
(ii) as to any particular requirement, a determination is made by
counsel for the Company that such requirement need not be met in
the circumstances under the then applicable securities laws.

(g)  Termination of Employment or Relationship as a Director or
Consultant.  In the event that an Optionee's Continuous Status as
an Employee, Director or Consultant terminates (other than upon
the Optionee's death or Disability), the Optionee may exercise
his or her Option, but only within such period of time as is
determined by the Board (which period shall not be less than
thirty (30) days from the date of such termination), and only to
the extent that the Optionee was entitled to exercise it at the
date of termination (but in no event later than the expiration of
the term of such Option as set forth in the Option Agreement).
If, at the date of termination, the Optionee is not entitled to
exercise his or her entire Option, the shares covered by the
unexercisable portion of the Option shall revert to the Plan.
If, after termination, the Optionee does not exercise his or her
Option within the time specified in the Option Agreement, the
Option shall terminate, and the shares covered by such Option
shall revert to the Plan.

(h)  Disability of Optionee.  In the event an Optionee's
Continuous Status as an Employee, Director or Consultant
terminates as a result of the Optionee's Disability), the
Optionee may exercise his or her Option, but only within twelve
(12) months from the date of such termination (or such period of
time as is determined by the Board which period shall not be less
than six (6) months from the date of such termination), and only
to the extent that the Optionee was entitled to exercise it at
the date of such termination (but in no event later than the
expiration of the term of such Option as set forth in the Option
Agreement).  If, at the date of termination, the Optionee is not
entitled to exercise his or her entire Option, the shares covered
by the unexercisable portion of the Option shall revert to the
Plan.  If, after termination, the Optionee does not exercise his
or her Option within the time specified herein, the Option shall
terminate, and the shares covered by such Option shall revert to
the Plan.

(i)  Death of Optionee.  In the event of the death of an
Optionee, the Option may be exercised, at any time within twelve
(12) months following the date of death (or such period of time
as is determined by the Board which period shall not be less than
six (6) months following the date of death) by the Optionee's
estate or by a person who acquired the right to exercise the
Option by bequest or inheritance, and only to the extent the
Optionee was entitled to exercise the Option at the date of death
(but in no event later than the expiration of the term of such
Option as set forth in the Option Agreement).  If, at the time of
death, the Optionee was not entitled to exercise his or her
entire Option, the shares covered by the unexercisable portion of
the Option shall revert to the Plan.  If, after death, the
Optionee's estate or a person who acquired the right to exercise
the Option by bequest or inheritance does not exercise the Option
within the time specified herein, the Option shall terminate, and
the shares covered by such Option shall revert to the Plan.

(j)  Withholding.  To the extent provided by the terms of an
Option Agreement, the Optionee may satisfy any federal, state or
local tax withholding obligation relating to the exercise of such
Option by any of the following means or by a combination of such
means:  (1) tendering a cash payment; (2) authorizing the Company
to withhold shares from the shares of the common stock otherwise
issuable to the participant as a result of the exercise of the
Option; or (3) delivering to the Company owned and unencumbered
shares of the common stock of the Company.

7.   COVENANTS OF THE COMPANY.

(a)  During the terms of the Options, the Company shall keep
available at all times the number of shares of stock required to
satisfy such Options.

(b)  The Company shall seek to obtain from each regulatory
commission or agency having jurisdiction over the Plan such
authority as may be required to issue and sell shares of stock
upon exercise of the Options; provided, however, that this
undertaking shall not require the Company to register under the
Securities Act either the Plan, any Option or any stock issued or
issuable pursuant to any such Option.  If, after reasonable
efforts, the Company is unable to obtain from any such regulatory
commission or agency the authority which counsel for the Company
deems necessary for the lawful issuance and sale of stock under
the Plan, the Company shall be relieved from any liability for
failure to issue and sell stock upon exercise of such Options
unless and until such authority is obtained.

8.   USE OF PROCEEDS FROM STOCK.

Proceeds from the sale of stock pursuant to Options shall
constitute general funds of the Company.

9.   MISCELLANEOUS.

(a)  Neither an Optionee nor any person to whom an Option is
transferred under subsection 6(d) shall be deemed to be the
holder of, or to have any of the rights of a holder with respect
to, any shares subject to such Option unless and until such
person has satisfied all requirements for exercise of the Option
pursuant to its terms.

(b)  Nothing in the Plan or any instrument executed or Option
granted pursuant thereto shall confer upon any Employee,
Director, Consultant or Optionee any right to continue in the
employ of the Company or any Affiliate (or to continue acting as
a Director or Consultant) or shall affect the right of the
Company or any Affiliate to terminate the employment or
relationship as a Director or Consultant of any Employee,
Director, Consultant or Optionee with or without cause.

(c)  To the extent that the aggregate fair market value
(determined at the time of grant) of stock with respect to which
Incentive Stock Options granted after 1986 are exercisable for
the first time by any Optionee during any calendar year under all
plans of the Company and its Affiliates exceeds one hundred
thousand dollars ($100,000), the Options or portions thereof
which exceed such limit (according to the order in which they
were granted) shall be treated as Nonstatutory Stock Options.

10.  ADJUSTMENTS UPON CHANGES IN STOCK.

(a)  If any change is made in the stock subject to the Plan, or
subject to any Option (through merger, consolidation,
reorganization, recapitalization, stock dividend, dividend in
property other than cash, stock split, liquidating dividend,
combination of shares, exchange of shares, change in corporate
structure or otherwise), the Plan and outstanding Options will be
appropriately adjusted in the class(es) and maximum number of
shares subject to the Plan and the class(es) and number of shares
and price per share of stock subject to outstanding Options.

(b)  In the event of:  (1) a merger or consolidation in which the
Company is not the surviving corporation or (2) a reverse merger
in which the Company is the surviving corporation but the shares
of the Company's common stock outstanding immediately preceding
the merger are converted by virtue of the merger into other
property, whether in the form of securities, cash or otherwise
then to the extent permitted by applicable law:  (i) any
surviving corporation shall assume any Options outstanding under
the Plan or shall substitute similar Options for those
outstanding under the Plan, or (ii) such Options shall continue
in full force and effect.  In the event any surviving corporation
refuses to assume or continue such Options, or to substitute
similar options for those outstanding under the Plan, then such
Options shall be terminated if not exercised prior to such event.
In the event of a dissolution or liquidation of the Company, any
Options outstanding under the Plan shall terminate if not
exercised prior to such event.

11.  AMENDMENT OF THE PLAN.

(a)  The Board at any time, and from time to time, may amend the
Plan.  However, except as provided in Section 10 relating to
adjustments upon changes in stock, no amendment shall be
effective unless approved by the shareholders of the Company
within twelve (12) months before or after the adoption of the
amendment, where the amendment will:

(i)  Increase the number of shares reserved for Options under the
Plan;

(ii) Modify the requirements as to eligibility for participation
in the Plan (to the extent such modification requires shareholder
approval in order for the Plan to satisfy the requirements of
Section 422 of the Code); or

(iii)     Modify the Plan in any other way if such modification
requires shareholder approval in order for the Plan to satisfy
the requirements of Section 422 of the Code or to comply with the
requirements of Rule 16b-3.

(b)  It is expressly contemplated that the Board may amend the
Plan in any respect the Board deems necessary or advisable to
provide Optionees with the maximum benefits provided or to be
provided under the provisions of the Code and the regulations
promulgated thereunder relating to Incentive Stock Options and/or
to bring the Plan and/or Incentive Stock Options granted under it
into compliance therewith.

(c)  Rights and obligations under any Option granted before
amendment of the Plan shall not be altered or impaired by any
amendment of the Plan unless (i) the Company requests the consent
of the person to whom the Option was granted and (ii) such person
consents in writing.

12.  TERMINATION OR SUSPENSION OF THE PLAN.

(a)  The Board may suspend or terminate the Plan at any time.
Unless sooner terminated, the Plan shall terminate on August 1,
2002.  No Options may be granted under the Plan while the Plan is
suspended or after it is terminated.

(b)  Rights and obligations under any Option granted while the
Plan is in effect shall not be altered or impaired by suspension
or termination of the Plan, except with the consent of the person
to whom the Option was granted.

13.  EFFECTIVE DATE OF THE PLAN.

The Plan shall become effective as determined by the Board, but
no Options granted under the Plan shall be exercised unless and
until the Plan has been approved by the shareholders of the
Company, and, if required, an appropriate permit has been issued
by the Commissioner of Corporations of the State of California.





EXHIBIT 23.1




CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the
Registration Statements (Form S-3 and S-8) of our report
dated August 21, 1998, with respect to the financial
statements of Cypros Pharmaceutical Corporation included in
the Annual Report (Form 10-K) for the year ended July 31,
1998.



ERNST & YOUNG LLP


San Diego, California
October 26, 1998



 

5 This schedule contains summary financial information extracted from the Form 10-K for the Period Ended July 31, 1998 and is qualified in its entirety by reference to such financial statements 12-MOS JUL-31-1998 JUL-31-1998 3,015,890 10,428,580 516,886 0 83,078 214,765 1,893,120 (829,554) 19,735,640 881,483 157,656 0 0 41,328,470 (22,817,138) 19,735,640 3,445,955 3,445,955 770,437 770,437 9,139,410 0 68,293 (5,572,869) 0 (5,572,869) 0 0 0 (5,572,869) (0.37) (0.37)


F-1
  
Form 10-K Items 14(a) (1) and (2)

Cypros Pharmaceutical Corporation

Years ended July 31, 1998, 1997 and 1996
with Report of Independent Auditors




Cypros Pharmaceutical Corporation

Form 10-K Items 14(a) (1) and (2)

Contents > Report of Ernst & Young LLP, Independent Auditors ......F-2 Audited Financial Statements (Item 14(a) (1)): Balance Sheets ......F-3 Statements of Operations ......F-4 Statements of Shareholders' Equity ......F-5 Statements of Cash Flows ......F-6 Notes to Financial Statements ......F-7
Financial Statement Schedules (Item 14(a) (2)): All financial statement schedules are omitted because the information described therein is not applicable, not required or is furnished in the financial statements or notes thereto. Report of Ernst & Young LLP, Independent Auditors The Board of Directors and Shareholders Cypros Pharmaceutical Corporation We have audited the accompanying balance sheets of Cypros Pharmaceutical Corporation as of July 31, 1998 and 1997, and the related statements of operations, shareholders' equity, and cash flows for each of the three years in the period ended July 31, 1998. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with generally accepted auditing standards. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of Cypros Pharmaceutical Corporation at July 31, 1998 and 1997, and the results of its operations and its cash flows for each of the three years in the period ended July 31, 1998, in conformity with generally accepted accounting principles. ERNST & YOUNG LLP San Diego, California August 21, 1998 Cypros Pharmaceutical Corporation Balance Sheets
July 31, 1998 1997 Assets Current assets: Cash and cash equivalents (Note 3) $ 3,015,890 $ 5,101,710 Short-term investments, held to maturity (Note 3) 10,428,580 9,465,561 Accounts receivable 516,886 355,425 Inventories (Note 3) 83,078 93,177 Prepaid expenses and other current assets 214,765 75,038 Total current assets 14,259,199 15,090,911 Property, equipment and leasehold improvements, net (Note 3) 1,063,566 675,686 Purchased technology, net of accumulated amortization of $2,118,226 and $1,220,838 at July 31, 1998 and 1997,respectively (Note 2) 4,163,487 5,060,875 Deferred financing costs, net of accumulated amortization of $520,011 and $260,884 at July 31, 1998 and 1997, respectively - 259,127 Licenses and patents, net of accumulated amortization of $160,212 and $118,376 at July 31, 1998 and 1997, respectively 176,927 162,592 Other assets 72,461 95,525 Total assets $19,735,640 $21,344,716 Liabilities and shareholders' equity Current liabilities: Accounts payable $ 551,191 365,386 Accrued compensation 125,434 109,778 Other accrued liabilities 15,641 118,658 Purchased asset obligations (Note 2) - 1,272,000 Current portion of long-term debt (Note 4) 97,477 41,367 Current portion of capital lease obligations (Note 5) 91,740 106,206 Total current liabilities 881,483 2,013,395 Long-term debt (Note 4) 59,408 - Capital lease obligations (Note 5) 157,656 148,787 Deferred rent 125,761 129,165 Mandatorily convertible notes (Note 5) - 4,027,461 Shareholders' equity (Note 6): Common stock, 30,000,000 shares authorized, 15,711,877 and 13,650,405 shares issued and outstanding as of July 31, 1998 and 1997, respectively 41,328,470 32,344,793 Deferred compensation (87,334) (161,950) Accumulated deficit (22,729,804)(17,156,935) Total shareholders' equity 18,511,332 15,025,908 Total liabilities and shareholders'equity $19,735,640 $21,344,716
See accompanying notes. Cypros Pharmaceutical Corporation Statements of Operations
Years ended July 31, 1998 1997 1996 Net sales $ 3,445,955 $ 2,428,348 $ 1,275,240 Cost of sales 770,437 538,725 405,142 Gross profit 2,675,518 1,889,623 870,098 Operating expenses: Sales and marketing 1,309,963 993,765 343,054 General and administrative 3,246,619 2,396,465 1,642,152 Clinical testing and regulatory 2,521,386 1,967,334 1,389,128 Pre-clinical research and development 822,225 1,032,486 1,002,226 Depreciation and amortization 1,239,217 1,075,431 611,848 Total operating expenses 9,139,410 7,465,481 4,988,408 Loss from operations (6,463,892) (5,575,858) (4,118,310) Research grant income 169,834 98,785 270,510 Interest and other income, net 809,254 662,421 757,692 Sublease income, net(Note 5) 171,062 - - Amortization of discount and costs on mandatorily converible notes (Note 5 ) (259,127) (1,860,051) - Net loss $(5,572,869)$(6,674,703) $(3,090,108) Net loss per share, basic and diluted $(0.37) $(0.54) $(0.27) Shares used in computing net loss per share, basic diluted 15,186,984 12,303,274 11,518,169
See accompanying notes. Cypros Pharmaceutical Corporation Statements of Shareholders' Equity Years ended July 31, 1998, 1997 and 1996
Common Stock Deferred Shares Amount Compensation Balance at July 31, 1995 11,352,017 $20,944,995 $(186,993) Discount on mandatorily convertible notes - 1,582,935 - notes Issuance of common stock, net of offering costs 162,500 940,956 - offering costs Issuance of common stock in business acquisitions 169,231 1,032,309 - Issuance of common stock for services 200,000 284,375 (284,375) Common stock repurchased (280,000) (1,540,000) - Exercise of stock options 10,000 35,163 - Deferred compensation related to grant of stock options - 140,695 (140,695) grant of stock options Amortization of deferred compensation - - 307,754 Net loss - - - Balance at July 31, 1996 11,613,748 23,421,428 (304,309) Conversion of mandatorily convertible notes 953,907 3,972,538 - Issuance of common stock, net of offering costs 1,075,000 4,714,507 - Exercise of stock options 7,750 21,963 - Forfeitures of stock options - (52,568) 52,568 Deferred compensation related to grant of stock options - 266,925 (266,925) Amortization of deferred compensation - - 356,716 Net loss - - - Balance at July 31, 1997 13,650,405 32,344,793 (161,950) Conversion of mandatorily convertible notes 1,205,446 4,025,588 - Issuance of common stock upon exercise of B Warrants 856,026 4,707,576 - Deferred compensation related to grant of stock options - 250,513 (250,513) Amortization of deferred compensation - - 325,129 Net loss - - - Balance at July 31, 1998 15,711,877$41,328,470 $(87,334)
Cypros Pharmaceutical Corporation Statements of Shareholders' Equity (Continued)
Accumulated Total Deficit Equity Balance at July 31, 1995 $ (7,392,124) $13,365,878 Discount on mandatorily convertible notes - 1,582,935 Issuance of common stock, net of offering costs - 940,956 Issuance of common stock in business acquisitions - 1,032,309 Issuance of common stock for services - - Common stock repurchased - (1,540,000) Exercise of stock options - 35,163 Deferred compensation related to grant of stock options - - Amortization of deferred compensation - 307,754 Net loss (3,090,108) (3,090,108) Balance at July 31, 1996 (10,482,232) 12,634,887 Conversion of mandatorily convertible notes - 3,972,538 Issuance of common stock, net of offering costs - 4,714,507 Exercise of stock options - 21,963 Forfeitures of stock options - - Deferred compensation related to grant of stock options - - Amortization of deferred compensation - 356,716 Net loss (6,674,703) (6,674,703) Balance at July 31, 1997 (17,156,935) 15,025,908 Conversion of mandatorily convertible notes - 4,025,588 Issuance of common stock upon exercise of B Warrants - 4,707,576 Deferred compensation related - to grant of stock options - - Amortization of deferred - compensation - 325,129 Net loss (5,572,869) (5,572,869) Balance at July 31, 1998 $(22,729,804)$18,511,332
See accompanying notes. Cypros Pharmaceutical Corporation Statements of Cash Flows
Years ended July 31, 1998 1997 1996 Operating activities Net loss $(5,572,869 $(6,674,703) $(3,090,108) Adjustments to reconcile net loss to net cash used in operating activities: Amortization of deferred compensation 325,129 356,716 307,754 Depreciation and amortization 1,239,217 1,075,431 611,848 Amortization of discount and costs on mandatorily convertible notes 259,127 1,860,051 - Deferred rent (3,404) (16,215) 39,892 Write-off of patent 41,311 - - Changes in operating assets and liabilities, net of effects from acquisitions: Accounts receivable (161,461) (205,799) (149,626) Inventory 10,099 (29,791) 18,829 Prepaid expenses and other current expenses (139,727) (13,629) 18,536 Accounts payable 185,805 246,294 (19,445) Accrued compensation and other accrued liabilities (87,361) (56,948) 114,305 Net cash flows used in operating activities (3,904,134) (3,458,593) (2,148,015) Investing activities Short-term investments (963,019) (2,537,126) 1,486,815 Investment in purchased technology - (2,014,048) (1,835,356) Installment payment for purchased technology (1,272,000) (200,000) (82,215) Purchase of property, equipment and leasehold improvements (587,265) (239,941) (100,770) Increase in licenses and patents (97,482) (82,460) (37,499) Decrease in other assets 23,064 21,375 6,197 Net cash flows used in investing activities (2,896,702) (5,052,200) (562,828) Financing activities Issuance of common stock, net 4,707,576 4,736,470 976,119 Cash paid for repurchase of mandatorily convertible notes (1,873) - - Issuance of mandatorily convertible notes - - 7,458,498 Repurchase and retirement of common stock - - (1,540,000) Issuance of long-term debt 209,406 - - Repayment of long-term debt (93,888) (99,282) (99,283) Repayments of capital lease obligations (106,205) (93,299) (42,622) Net cash flows provided by financing activities 4,715,016 4,543,889 6,752,712 Increase (decrease) in cash and cash equivalents (2,085,820) (3,966,904) 4,041,869 Cash and cash equivalents at beginning of year 5,101,710 9,068,614 5,026,745 Cash and cash equivalents at end of year $3,015,890 $5,101,710 $9,068,614 Supplemental disclosures of cash flow information: Cash paid for interest $ 132,269 $ 123,997 $ 47,953 Noncash investing and financing activities: Conversion of mandatorily convertible notes $4,025,588 $ 3,972,538 $ - Equipment financed under capital lease obligations $ 100,608 $ 79,992 $ 234,256 Purchased asset obligation incurred for acquisition $ - $ 1,200,000 $ 200,000 Common stock issued for acquisitions $ - $ - $ 1,032,309
See accompanying notes. Cypros Pharmaceutical Corporation Notes to Financial Statements July 31, 1998 1. Organization and Summary of Significant Accounting Policies Organization and Business Activity Cypros Pharmaceutical Corporation (the "Company") was incorporated in San Diego, California on November 2, 1990. The Company develops and markets acute-care, hospital-based products. The Company is currently marketing three products, Ethamolin, Glofil and Inulin, will be launching two burn/wound care products and is developing two drugs, Cordox (formerly CPC-111) and Ceresine. The Company's pre-clinical and clinical development programs focus on cytoprotective drugs designed to reduce ischemia (low blood flow) induced tissue damage in acute-care settings and Cordox and Ceresine are in late-stage clinical trials in two settings: sickle cell crisis and traumatic brain injury. Cash, Cash Equivalents and Short-Term Investments The Company considers highly liquid investments with remaining maturities of three months or less when acquired to be cash equivalents. Short-term investments consist of certificates of deposit, money market funds, U.S. government obligations and investment grade corporate debt securities. The Company has established guidelines relative to diversification and maturities that maintain safety and liquidity. The Company has not experienced any losses on its cash equivalents or short-term investments. Management believes the credit risk associated with these investments is limited due to the nature of the investments. Management determines the appropriate classification of debt securities at the time of purchase and reevaluates such designations as of each balance sheet date. Debt securities are classified as held-to-maturity when the Company has the positive intent and the ability to hold the securities to maturity. Held-to-maturity securities are carried at cost, adjusted for amortization of premiums and accretion of discounts. Interest, dividends and amortization on the securities classified as held-to-maturity are included in interest income. Concentration of Credit Risk The Company extends credit to its customers, primarily hospitals and large pharmaceutical companies conducting clinical research, in connection with its product sales. The Company has not experienced significant credit losses on its customer accounts. Two customers individually accounted for 23% and 12% of current year sales. Inventories Inventories are stated at the lower of cost (first-in, first-out method) or market. Depreciation and Amortization Property and equipment are stated at cost and depreciated over the estimated useful lives of the assets (generally five years) using the straight-line method. Leasehold improvements are amortized over the lesser of the estimated useful lives (seven years) or the remaining term of the lease. Purchased Technology Purchased technology associated with the acquisitions of Glofil, Inulin and Ethamolin is stated at cost and amortized over the period estimated to be benefited (seven years). Deferred Financing Costs The Company deferred banking, legal and accounting fees associated with the issuance of $8 million in principal amount of mandatorily convertible notes in 1996. These costs were amortized over the term of the notes, which was three years, using the effective interest method commencing with the closing of the transactions. In fiscal 1998, upon the conversion of the remaining balance of the notes, all such costs were fully amortized. License and Patent Costs The Company capitalizes certain costs related to license rights and patent applications. Accumulated costs are amortized over the estimated economic lives of the license rights and patents (generally six years) commencing at the time the license rights are granted or the patents are issued. Accounting Standard on Impairment of Long-Lived Assets In accordance with Statement of Financial Accounting Standards No. 121, Accounting for the Impairment of Long-Lived Assets and for Long-Lived Assets to Be Disposed Of ("SFAS 121"), the Company regularly evaluates its long- lived assets for indicators of possible impairment. To date, no such indicators have been identified. Revenue Recognition Revenues from product sales of Ethamolin and whole vials of Glofil and Inulin are recognized upon shipment. Revenues from Glofil unit dose sales are recognized upon receipt by the Company of monthly sales reports from its third-party distributor. The Company is not obligated to accept returns of products sold that have reached their expiration date. Net Loss Per Share In the second quarter of the fiscal year ended July 31, 1998, the Company adopted Statement of Financial Accounting Standards No. 128, Earnings Per Share ("SFAS 128"), which replaced the calculation of primary and fully diluted net loss per share with basic and diluted net income or loss per share. Basic net income or loss per share is calculated using the weighted average number of common shares outstanding. Diluted net income or loss per share is calculated using the weighted average number of common shares outstanding plus the dilutive effect of options and warrants, if any, using the treasury stock method. All net loss per share amounts for all periods have been presented, and where appropriate restated, to conform to the SFAS 128 requirements and the recently effective Securities and Exchange Commission Staff Accounting Bulletin No. 98. Stock Options The Company has elected to follow Accounting Principles Board Opinion No. 25, Accounting for Stock Issued to Employees ("APB 25") and related Interpretations in accounting for its employee stock options because the alternative fair value accounting provided for under Statement of Financial Accounting Standards No. 123, Accounting for Stock-Based Compensation ("SFAS 123") requires use of option valuation models that were not developed for use in valuing employee stock options. Under APB 25, when the exercise price of the Company's employee stock options equals or exceeds the market price of the underlying stock on the date of grant, no compensation expense is recognized. Recently Issued Accounting Standards Effective August 1, 1998, the Company will adopt Statement of Financial Accounting Standards No. 130, Reporting Comprehensive Income (Loss) ("SFAS 130"). SFAS 130 requires that all components of comprehensive income (loss), including net income (loss), be reported in the financial statements in the period in which they are recognized. Comprehensive income (loss) is defined as the change in equity during the period from transactions and other events and circumstances from non-owner sources. Net income (loss) and other comprehensive income (loss), including unrealized gains and losses on investments, shall be reported, net of their related tax effect, to arrive at comprehensive income (loss). The Company does not believe comprehensive loss will be different than the net loss previously reported. Effective August 1, 1998, the Company will adopt Statement of Financial Accounting Standards No. 131, Disclosures about Segments of an Enterprise and Related Information ("SFAS 131"). SFAS 131 redefines segments and requires companies to report financial and descriptive information about their operating segments. The Company has determined that it operates in one business segment and therefore the adoption of SFAS 131 will not affect the Company's financial statements. Use of Estimates The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the financial statements and disclosures made in the accompanying notes to the financial statements. Actual results could differ from those estimates. Reclassifications Certain previously reported amounts have been reclassified to conform with the 1998 presentation. 2. Acquisitions On August 9, 1995, the Company acquired two businesses, including (i) the New Drug Application for Glofil and finished goods inventory of Glofil on hand at the time of closing from Iso-Tex Diagnostics, Inc., a Texas corporation, (the "Glofil Acquisition") and (ii) the New Drug Application for Inulin and the raw material and finished goods inventory of Inulin on hand at the time of closing from Iso-Tex Diagnostics "B," Inc. ("ITDB"), a Texas corporation (the "Inulin Acquisition"). The Glofil Acquisition was accomplished in an arms' length negotiation through a purchase of assets and the Inulin Acquisition was accomplished through a merger of ITDB with and into the Company (the "Merger"). The total purchase price was $3,149,880, of which the Company paid $1,582,215 in cash from its working capital and issued 169,231 shares of restricted Common Stock of the Company (the "Restricted Shares") which were paid at closing. As part of the Glofil Acquisition, the Company made an additional cash payment of $200,000 on January 15, 1996 and a final cash payment of $200,000 on August 9, 1996. On November 4, 1996, the Company acquired the New Drug Application, the U.S. trademark for Ethamolin Injection (the "Ethamolin Assets") and the finished goods inventory on hand at closing from Schwarz Pharma, Inc., a Delaware corporation. The total purchase price was $3,286,642, of which the Company paid $2,086,642 in cash from its working capital and issued a $1,200,000 8% note (the "Schwarz Note") which was paid in full during fiscal year 1998. All of these acquisitions were accounted for using the purchase method and, accordingly, the financial statements include the operations of the businesses from the date of acquisition. The following unaudited pro forma data reflects the combined results of operations of the Company as if the Glofil Acquisition and the Inulin Acquisition had occurred on August 1, 1994 and the Ethamolin acquisition had occurred on August 1, 1995:
Years end July 31, 1997 1996 Net sales $2,752,691 $2,402,006 Net loss (6,394,987) (2,679,376) Net loss per share (0.52) (0.23)
3. Financial Statement Details Short-Term Investments All short-term investments of the Company are classified as held-to-maturity. The following is a summary of held-to-maturity investments at amortized cost at July 31:
1998 1997 Corporate debt securities $ 9,933,424 $10,465,202 Money market funds 2,656,423 2,723,458 U.S. government obligations 495,156 995,770 13,085,003 14,184,430 Less: amounts classified as cash equivalents (2,656,423) (4,718,869) Short-term investments $10,428,580 $ 9,465,561
As of July 31, 1998, the difference between cost and estimated fair value of the held-to-maturity investments was not significant. Of the above-referenced 1998 investments, $6,265,682 mature at various dates through July 31, 1999 and $4,162,898 will mature at various dates after July 31, 1999 through December 14, 2001. Inventories Inventories consist of the following at July 31:
1998 1997 Raw materials $ 2,087 $ 4,252 Finished goods 80,991 88,925 $83,078 $93,177
Property, Equipment and Leasehold Improvements Property, equipment and leasehold improvements consist of the following at July 31:
1998 1997 Laboratory equipment $756,525 $785,573 Office equipment, furniture and fixtures 783,446 284,902 Leasehold improvements 353,149 134,772 1,893,120 1,205,247 Less accumulated depreciation and amortization (829,554) (529,561) $1,063,566 $ 675,686
Depreciation and amortization expense totaled $299,993, $252,453 and $138,471 for the years ended July 31, 1998, 1997 and 1996, respectively. 4. Long-Term Debt Long-term debt consists of the following at July 31: CAPTION> 1998 1997 Note payable to a pharmaceutical company due November 1999, collateralized by certain purchased assets totaling $234,000, bearing interest at 8% until November 1998 and 4% thereafter, payable in three semiannual installments starting November 1998, of $39,300, $46,200 and $48,500, plus interest $142,025 $ - Note payable to a leasing company due November 2001, collateralized by real property, bearing interest at 10%, payable in 53 monthly installments of $438 including interest 14,860 - Note payable to a financial institution due December 1997, collateralized by $84,048 of the Company's short-term investments at July 31, 1997, bearing interest at prime plus 1.6% (10.10% at July 31, 1997) - 41,367 156,885 41,367 Less current portion (97,477) (41,367) Total $ 59,408 $ -
Interest expense incurred on these notes totaled $10,748, $9,524 and $19,897 for the years ended July 31, 1998, 1997 and 1996, respectively. 5. Commitments Leases The Company leases its office and research facilities under operating lease agreements and certain equipment under capital lease agreements. A security deposit of $64,260 under one of the facilities lease agreements is included in other assets. Minimum future obligations under both operating and capital leases as of July 31, 1998 are as follows:
Operating Capital Leases Leases 1999 $464,942 $108,903 2000 491,649 87,794 2001 418,356 33,111 2002 127,310 25,061 2003 25,061 Thereafter - 10,443 $1,502,257 290,373 Less amounts representing interest (40,977) Present value of net minimum lease payments 249,396 Current portion of capital lease obligations (91,740) Long-term capital lease obligations $157,656
Rent expense totaled $445,095, $420,697 and $193,880 for the years ended July 31, 1998, 1997 and 1996, respectively. The net book value of the equipment acquired under capital leases totaled $222,101 and $228,878 (net of accumulated amortization of $288,732 and $181,347) at July 31, 1998 and 1997, respectively. Rent expense comprises the cost associated with two buildings leased by the Company, its current headquarters located at 2714 Loker Avenue West in Carlsbad, California and its former headquarters located at 2732 Loker Avenue West. In April 1996, the Company subleased its former headquarters for the remainder of the original lease term plus an additional 36 month option. Net sublease income totaled $171,062 for the year ended July 31, 1998. Scheduled aggregate future sublease income at July 31, 1998 is approximately $1,128,081. Mandatorily Convertible Notes During the year ended July 31, 1996, the Company issued $8 million in principal amount of non-interest bearing mandatorily convertible notes (the "Notes") to institutional investors in private placements under the provisions of the Securities and Exchange Commission (the "SEC") Regulation D. The Notes were convertible at the option of the investors into shares of the Company's Common Stock at various dates from January 31, 1997 through July 31, 1999 at a discount to the market price of the stock immediately preceding conversion, ranging from 15% to 25%, with the actual discount depending on the length of time each investor has held the note being converted. The Notes were all converted at various dates through July 31, 1998, except for $1,873 which was paid in cash. The Notes were recorded net of the $1,582,935 discount available upon conversion (assuming full conversion at the earliest possible dates), and the discount represents an effective interest rate of 33%. The discount has been added to Common Stock and was amortized to expense during fiscal year 1997. License Agreements The Company has licenses to various patents for Cordox and Ceresine, its two clinical development programs, for the remaining term of the patents. The license agreements require payments of cash, warrants or the issuance of stock options to the licensers upon accomplishment of various milestones and the payment of royalties to the licensers upon the commercial sale of products incorporating the licensed compound. The only remaining significant development milestone under these agreements is the requirement that the Company pay the licensor of Cordox $250,000 upon the filing of a New Drug Application with the Food and Drug Administration (the "FDA") for the approval to market that compound. In the event milestone or royalty payments to the licensor of Cordox are not made by the Company within specified time periods, that licensor may elect to terminate the license agreement and all rights thereunder. Such a termination could have a significant adverse impact upon the Company. 6. Shareholders' Equity Preferred Stock The Company has authorized 1,000,000 shares of convertible preferred stock. As of July 31, 1998 and 1997, no such shares were issued or outstanding. Warrants As of July 31, 1997, 4,673,512 Redeemable Class B Warrants were outstanding. In November 1997, the Company received net proceeds of $4,707,576 from the exercise of 856,026 Redeemable Class B Warrants and the concurrent issuance of 856,026 shares of Common Stock. During fiscal year 1998, all Redeemable Class B Warrants expired and none are outstanding at July 31, 1998. Stock Option Plans Pro forma information regarding net loss and loss per share is required by SFAS 123, and has been determined as if the Company has accounted for its employee stock options under the fair value method set forth in SFAS 123. The fair value of these options was estimated at the date of grant using the Black-Scholes option pricing model with the following weighted average assumptions for 1998, 1997 and 1996: risk-free interest rates of 6.0%; dividend yields of 0%; volatility factors of the expected market price of the Company's Common Stock of 79% for 1998 and 84% for 1997 and 1996; and the weighted-average life of the options of eight years. The Black-Scholes option valuation model was developed for use in estimating the fair value of traded options which have no vesting restrictions and are fully transferable. In addition, option valuation models require the input of highly subjective assumptions including the expected stock price volatility. Because the Company's employee stock options have characteristics significantly different from those of traded options, and because changes in the subjective input assumptions can materially affect the fair value estimate, in management's opinion, the existing models do not necessarily provide a single reliable measure of the fair value of its employee stock options. For purposes of pro forma disclosures, the estimated fair value of the options is amortized to expense over the options' vesting period. The Company's pro forma net loss for the years ended July 31, 1998, 1997 and 1996 is as follows:
1998 1997 1996 Pro forma net loss $(6,844,607) $(7,658,837) $(3,943,018) Pro forma net loss per share, basic and diluted $(0.45) $(0.62) $(0.34)
As of July 31, 1998, 2,766,288 shares of Common Stock were reserved for issuance under the 1992 Stock Option Plan (the "1992 Plan"). The 1992 Plan provides for the grant of incentive and nonstatutory stock options with various vesting periods, generally four years, to employees, directors and consultants. The exercise price of incentive stock options must equal at least the fair market value on the date of grant, and the exercise price of nonstatutory stock options may be no less than 85% of the fair market value on the date of grant. The maximum term of options granted under the 1992 Plan is ten years. In June 1993, the Company adopted the 1993 Non-Employee Directors' Stock Option Plan (the "1993 Plan"), under which 250,000 shares of Common Stock were reserved for issuance. The 1993 Plan provides for the granting of 25,000 options to purchase Common Stock upon appointment as a non-employee director and an additional 3,000 options each January thereafter, beginning January 1, 1994. Options vest over four years. The exercise price of the options is 85% of the fair market value on the date of grant. The maximum term of options granted under the 1993 Plan is ten years. The following table summarizes stock option activity under the 1992 and 1993 Plans:
Options Weighted Outstanding Average Exercise Price Balance at July 31, 1995 1,018,000 $3.83 Granted 360,000 $5.30 Exercised (10,000) $3.52 Canceled (12,188) $5.40 Balance at July 31, 1996 1,355,812 $4.21 Granted 309,499 $4.33 Exercised (7,750) $2.83 Canceled (219,125) $4.47 Balance at July 31, 1997 (1,438,436) $4.25 Granted 749,700 $4.85 Exercised - $ - Canceled (295,647) $5.08 Balance at July 31, 1998 1,892,489 $4.36
At July 31, 1998, options to purchase 1,254,699 shares of Common Stock were exercisable and there were 623,799 shares available for future grant under the 1992 and 1993 Plans. The weighted average grant-date fair value for the options granted during 1998, 1997 and 1996 were $3.74, $3.40 and $4.39, respectively. Exercise prices and weighted average remaining contractual life for the options outstanding under the 1992 and 1993 Plans as of July 31, 1998 are as follows:
Options Outstanding Options Exercisable Weighted Weighted Weighted Range of Average Average Average Exercise Number Remaining Exercise Number Exercise Price Outstanding Contractual Price Exercisable Price Life $1.44 97,500 4.05 $1.44 97,500 $1.44 $2.20-$2.46 93,000 4.78 $2.22 93,000 $2.32 $3.06-$4.00 571,833 7.74 $3.70 398,452 $3.70 $4.05-$4.95 293,449 7.89 $4.68 204,524 $4.42 $5.00-$5.75 717,958 6.03 $5.33 362,762 $5.33 $6.00-$6.80 76,249 5.10 $6.31 67,524 $6.31 $7.86-$8.50 42,500 7.03 $8.08 30,937 $8.08 1,892,489 $4.36 1,254,699
The Company has recorded deferred compensation for the difference between the price of options granted and the fair value of the Company's Common Stock. Deferred compensation is amortized to expense during the vesting period of the related stock or options. 7. Income Taxes The Company accounts for income taxes using the liability method under Financial Accounting Standards Board Statement No. 109, Accounting for Income Taxes. Deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of the Company's deferred tax assets and liabilities as of July 31, 1998 and 1997 are as follows:
1998 1997 Deferred tax liabilities: Purchased technology $ 267,000 $ 423,000 Total Deferred tax liabilities 267,000 423,000 Deferred tax assets: Net operating loss carryforwards 6,439,000 4,554,000 Capitalized research and development costs 569,000 547,000 Research and development tax credit carryforwards 836,00 530,000 Other - net 53,000 1,243,000 Total deferred tax assets 7,897,000 6,874,000 Valuation allowance (7,630,000) (6,451,000) Net deferred tax assets $ - $ -
At July 31, 1998, the Company has federal and California tax net operating loss carryforwards of approximately $17,520,000 and $5,335,000, respectively. The federal tax loss carryforwards will begin to expire in 2007, unless previously utilized. The California tax loss carryforwards began expiring in 1997 (approximately $340,000 expired in 1998 and will continue to expire unless previously utilized). The Company also has federal and California research and development tax credit carryforwards of approximately $666,000 and $263,000, respectively, which will begin expiring in 2007 unless previously utilized. The above carryforwards were determined as if the Company were filing a tax return at July 31, 1998; however, for tax return purposes the Company uses a calendar year end. In accordance with the Internal Revenue Code, the use of the Company's net operating loss and credit carryforwards may be limited upon cumulative changes in ownership of more than 50%. The valuation allowance increased $1,179,000 from July 31, 1997 to July 31, 1998 due principally to the increase in deferred tax assets resulting from the increase in tax net operating loss carryforwards. Realization of deferred tax assets is dependent on future earnings, the timing and amount of which will be dependent on scientific success, results of clinical trials and regulatory approval of the Company's products currently under development. Accordingly, the full valuation reserve has been established to reflect these uncertainties. 8. Legal Proceedings In July 1998, the Company was served with a complaint in the United States Bankruptcy Court for the Southern District of New York by the Trustee for the liquidation of the business of A. R. Baron & Co., Inc. ("A.R. Baron") and the Trustee of The Baron Group, Inc. (the "Baron Group"), the parent of A. R. Baron. The complaint alleges that A. R. Baron and the Baron Group made certain preferential or fraudulent transfers of funds to the Company prior to the commencement of bankruptcy proceedings involving A. R. Baron and the Baron Group. The Trustee is seeking return of the funds totaling $3.2 million. The Company believes that the Trustee's claims are unfounded and intends to contest the allegations in the complaint vigorously. The Company contends that the transfers challenged by the Trustee relate to (i) the exercise by A. R. Baron in 1995 of unit purchase options issued to it in 1992 as part of its negotiated compensation for underwriting the Company's initial public offering and (ii) the repayment by the Baron Group of the principal and interest (at 12% per annum) payments and certain loan extension fees related to certain collateralized loans made to it by the Company in 1995 and 1996. The Company believes that it has insurance coverage sufficient to cover any costs, expenses, or losses that might be incurred in connection with this action. 9. Year 2000 Issue (unaudited) The Company has modified or replaced portions of its software so that its computer systems will function properly with respect to dates in the year 2000 and thereafter. The Company believes that, with these modifications to existing software and conversions to new software, the Year 2000 Issue will not pose significant operational problems for its computer systems.