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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 8 and Amendment No. 10)* QUESTCOR PHARMACEUTICALS INC. - -------------------------------------------------------------------------------- (Name of Issuer) Common Stock - -------------------------------------------------------------------------------- (Title of Class of Securities) 232808105 - -------------------------------------------------------------------------------- (CUSIP Number) Joseph J. Giunta, Esq. - -------------------------------------------------------------------------------- Skadden, Arps, Slate, Meagher & Flom LLP 300 South Grand Avenue Los Angeles, CA 90071 (213) 687-5000 - -------------------------------------------------------------------------------- (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications) December 13, 2006 - -------------------------------------------------------------------------------- (Date of Event which Requires Filing of this Statement) If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of ss.240.13d-1(e), 240.13d-1(f) or 240.13d-(1)(g), check the following box . *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13D - -------------------------------------------------------------------------------- CUSIP No. 232808105 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS Claudio Cavazza - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) |X| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION Italy - -------------------------------------------------------------------------------- 7 SOLE VOTING POWER NUMBER OF 0 SHARES ------------------------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 14,255,553 EACH REPORTING ------------------------------------------------- PERSON WITH 9 SOLE DISPOSITIVE POWER 1,756,781 10 SHARED DISPOSITIVE POWER 9,402,890 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 14,255,553 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES |_| - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 20.78% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON IN - -------------------------------------------------------------------------------- 2

SCHEDULE 13D - -------------------------------------------------------------------------------- CUSIP No. 232808105 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS Paolo Cavazza - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) |X| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS PF - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)Sigma-Tau Finanziaria SpA - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION Italy - -------------------------------------------------------------------------------- 7 SOLE VOTING POWER NUMBER OF 0 SHARES ------------------------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 14,255,553 EACH REPORTING ------------------------------------------------- PERSON WITH 9 SOLE DISPOSITIVE POWER 2,446,782 10 SHARED DISPOSITIVE POWER 10,051,990 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 14,255,553 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES |_| - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 20.78% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON IN - ------------------------------------------------------------------------------- 3

SCHEDULE 13D - -------------------------------------------------------------------------------- CUSIP No. 232808105 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS Sigma-Tau Finanziaria SpA - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) |X| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) |_| - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION Italy - -------------------------------------------------------------------------------- 7 SOLE VOTING POWER NUMBER OF 0 SHARES ------------------------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 14,255,553 EACH REPORTING ------------------------------------------------- PERSON WITH 9 SOLE DISPOSITIVE POWER 0 10 SHARED DISPOSITIVE POWER 9,402,890 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 14,255,553 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES |_| - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 20.78% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON CO - -------------------------------------------------------------------------------- 4

SCHEDULE 13D - -------------------------------------------------------------------------------- CUSIP No. 232808105 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS Sigma-Tau International S.A. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) |X| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) |_| - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION Luxembourg - -------------------------------------------------------------------------------- 7 SOLE VOTING POWER NUMBER OF 0 SHARES ------------------------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 14,255,553 EACH REPORTING ------------------------------------------------- PERSON WITH 9 SOLE DISPOSITIVE POWER 0 10 SHARED DISPOSITIVE POWER 9,402,890 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 14,255,553 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES |_| - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 20.78% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON CO - -------------------------------------------------------------------------------- 5

SCHEDULE 13D - -------------------------------------------------------------------------------- CUSIP No. 232808105 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS Defiante Farmaceutica L.D.A. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) |X| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) |_| - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION Portugal - -------------------------------------------------------------------------------- 7 SOLE VOTING POWER NUMBER OF 0 SHARES ------------------------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 14,255,553 EACH REPORTING ------------------------------------------------- PERSON WITH 9 SOLE DISPOSITIVE POWER 0 10 SHARED DISPOSITIVE POWER 759,493 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 14,255,553 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES |_| - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 20.78% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON CO - -------------------------------------------------------------------------------- 6

SCHEDULE 13D - -------------------------------------------------------------------------------- CUSIP No. 232808105 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS Aptafin S.p.A. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) |X| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) |_| - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION Italy - -------------------------------------------------------------------------------- 7 SOLE VOTING POWER NUMBER OF 0 SHARES ------------------------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 14,255,553 EACH REPORTING ------------------------------------------------- PERSON WITH 9 SOLE DISPOSITIVE POWER 0 10 SHARED DISPOSITIVE POWER 10,051,990 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 14,255,553 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES |_| - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 20.78% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON CO - -------------------------------------------------------------------------------- 7

SCHEDULE 13D - -------------------------------------------------------------------------------- CUSIP No. 232808105 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS Chaumiere - Consultadoria & Servicos SDC Unipessoal LDA - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) |X| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) |_| - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION Portugal - -------------------------------------------------------------------------------- 7 SOLE VOTING POWER NUMBER OF 0 SHARES ------------------------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 14,255,553 EACH REPORTING ------------------------------------------------- PERSON WITH 9 SOLE DISPOSITIVE POWER 0 10 SHARED DISPOSITIVE POWER 100,000 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 14,255,553 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES |_| - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 20.78% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON CO - -------------------------------------------------------------------------------- 8

Amendment No. 8 and Amendment No. 10 to Statement on Schedule 13D This Amendment No. 8 (the "Amendment No. 8") amends the Statement on Schedule 13D filed with the Securities and Exchange Commission ("SEC") on March 25, 2002 (the "Sigma/Defiante Schedule 13D"), as amended, relating to shares of the common stock, no par value (the "Common Stock"), of Questcor Pharmaceuticals Inc., a California corporation ("Questcor"). This Amendment No. 10 (the "Amendment No. 10" and, together with the Amendment No. 8, this "Statement") amends the Statement on Schedule 13D, filed with the SEC on August 7, 2001 (the "Cavazza/Sigma Schedule 13D" and, together with the Sigma/Defiante Schedule 13D, the "Schedule 13Ds"), as amended, relating to the shares of Common Stock. Pursuant to Rule 13d-2 of Regulation 13D-G promulgated under the Securities Exchange Act of 1934, as amended (the "Act"), this Amendment No. 8 is being filed on behalf of Sigma-Tau Finanziaria SpA, an Italian corporation ("Sigma Tau") and Defiante Farmaceutica L.D.A., a Portuguese corporation ("Defiante") (formerly known as Defiante Farmaceutica Unipessoal L.D.A.), and this Amendment No. 10 is being filed on behalf of Sigma-Tau International S.A., a Luxembourg corporation ("Sigma Tau International") (formerly known as Sigma-Tau Finance Holding S.A.), Aptafin S.p.A., an Italian corporation ("Aptafin"), Chaumiere - Consultadoria & Servicos SDC Unipessoal LDA, a Portuguese corporation ("Chaumiere"), Mr. Claudio Cavazza ("Mr. C. Cavazza") and Mr. Paolo Cavazza ("Mr. P. Cavazza" and, together with Mr. C. Cavazza, Sigma Tau International, Aptafin, Chaumiere, Defiante and Sigma Tau, the "Reporting Persons"). Item 3. Source and Amount of Funds or Other Consideration. Item 3 of the Schedule 13Ds are hereby amended to add the following: On December 13, 2006, Mr. P. Cavazza used personal funds to purchase 690,000 shares of Common Stock for a purchase price of $1.45 per share. Item 5. Interest in Securities of Questcor. Item 5 of the Schedule 13Ds are hereby amended as follows: The Reporting Persons, because they may be considered a "group" for purposes of Section 13(d)(3) of the Act (the "Group"), may be deemed solely for purposes of U.S. securities laws to beneficially own (i) the 1,756,781 shares of Common Stock directly owned by Mr. C. Cavazza, (ii) the 2,446,782 shares of Common Stock directly owned by Mr. P. Cavazza, (iii) the 8,643,397 shares of Common Stock directly owned by Sigma Tau International, (iv) the 759,493 shares of Common Stock directly owned by Defiante, (v) the 549,100 shares of Common Stock directly owned by Aptafin, and (vi) the 100,000 shares of Common Stock directly owned by Chaumiere. This represents beneficial ownership of an aggregate of 14,255,553 shares of Common Stock. References to beneficial ownership are made herein solely with respect to U.S. securities laws and are not intended to refer or apply in any respect to any other issue under any other U.S. law. (a) Percentage interest calculations for the Reporting Persons are based upon Questcor having 68,616,721 shares of Common Stock outstanding at the consummation of an offering of 11,400,000 shares of Common Stock (the "Offering"), as reported by the Issuer in the Issuer's Form 424B5 filed with the SEC on December 8, 2006. Mr. C. Cavazza Pursuant to Rule 13d-3 of the Act, Mr. C. Cavazza may be deemed to be the beneficial owner of 14,255,553 shares of Common Stock, which constitutes approximately 20.78% of the Outstanding Shares.

Mr. P. Cavazza Pursuant to Rule 13d-3 of the Act, Mr. P. Cavazza may be deemed to be the beneficial owner of 14,255,553 shares of Common Stock, which constitutes approximately 20.78% of the Outstanding Shares. Sigma Tau International Pursuant to Rule 13d-3 of the Act, Sigma Tau International may be deemed to be the beneficial owner of 14,255,553 shares of Common Stock, which constitutes approximately 20.78% of the Outstanding Shares. Sigma Tau Pursuant to Rule 13d-3 of the Act, Sigma Tau may be deemed to be the beneficial owner of 14,255,553 shares of Common Stock, which constitutes approximately 20.78% of the Outstanding Shares. Defiante Pursuant to Rule 13d-3 of the Act, Defiante may be deemed to be the beneficial owner of 14,255,553 shares of Common Stock, which constitutes approximately 20.78% of the Outstanding Shares. Aptafin Pursuant to Rule 13d-3 of the Act, Aptafin may be deemed to be the beneficial owner of 14,255,553 shares of Common Stock, which constitutes approximately 20.78% of the Outstanding Shares. Chaumiere Pursuant to Rule 13d-3 of the Act, Chaumiere may be deemed to be the beneficial owner of 14,255,553 shares of Common Stock, which constitutes approximately 20.78% of the Outstanding Shares. Except as set forth above, none of the Reporting Persons nor any of the persons listed on Schedule A beneficially owns any other shares of Common Stock. (b) Mr. C. Cavazza The number of shares of Common Stock as to which Mr. C. Cavazza has the sole power to vote or direct the vote is zero. The number of shares of Common Stock as to which Mr. C. Cavazza shares the power to vote or direct the vote is 14,255,553. The number of shares of Common Stock as to which Mr. C. Cavazza has the sole power to dispose or direct the disposition is 1,756,781. The number of shares of Common Stock as to which Mr. C. Cavazza shares the power to dispose or direct the disposition is 9,402,890. Mr. P. Cavazza The number of shares of Common Stock as to which Mr. P. Cavazza has the sole power to vote or direct the vote is zero. The number of shares of Common Stock as to which Mr. P. Cavazza shares the power to vote or direct the vote is 14,255,553. The number of shares of Common Stock as to which Mr. P. Cavazza has the sole power to dispose or direct the disposition is 2,446,782. The number of shares of Common Stock as to which Mr. P. Cavazza shares the power to dispose or direct the disposition is 10,051,990. Sigma Tau International 10

The number of shares of Common Stock as to which Sigma Tau International has the sole power to vote or direct the vote is zero. The number of shares of Common Stock as to which Sigma Tau International shares the power to vote or direct the vote is 14,255,553. The number of shares of Common Stock as to which Sigma Tau International has the sole power to dispose or direct the disposition is zero. The number of shares of Common Stock as to which Sigma Tau International shares the power to dispose or direct the disposition is 9,402,890. Sigma Tau The number of shares of Common Stock as to which Sigma Tau has the sole power to vote or direct the vote is zero. The number of shares of Common Stock as to which Sigma Tau shares the power to vote or direct the vote is 14,255,553. The number of shares of Common Stock as to which Sigma Tau has the sole power to dispose or direct the disposition is zero. The number of shares of Common Stock as to which Sigma Tau shares the power to dispose or direct the disposition is 9,402,890. Defiante The number of shares of Common Stock as to which Defiante has the sole power to vote or direct the vote is zero. The number of shares of Common Stock as to which Defiante shares the power to vote or direct the vote is 14,255,553. The number of shares of Common Stock as to which Defiante has the sole power to dispose or direct the disposition is zero. The number of shares of Common Stock as to which Defiante shares the power to dispose or direct the disposition is 759,493. Aptafin The number of shares of Common Stock as to which Aptafin has the sole power to vote or direct the vote is zero. The number of shares of Common Stock as to which Aptafin shares the power to vote or direct the vote is 14,255,553. The number of shares of Common Stock as to which Aptafin has the sole power to dispose or direct the disposition is zero. The number of shares of Common Stock as to which Aptafin shares the power to dispose or direct the disposition is 10,051,990. Chaumiere The number of shares of Common Stock as to which Chaumiere has the sole power to vote or direct the vote is zero. The number of shares of Common Stock as to which Chaumiere shares the power to vote or direct the vote is 14,255,553. The number of shares of Common Stock as to which Chaumiere has the sole power to dispose or direct the disposition is zero. The number of shares of Common Stock as to which Chaumiere shares the power to dispose or direct the disposition is 100,000. (c) On December 13, 2006, Mr. P. Cavazza purchased 690,000 shares of Common Stock in the Offering for a purchase price of $1.45 per share. Item 7. Material to be Filed as Exhibits. Item 7 of the Schedule 13Ds are hereby amended to add the following: EXHIBIT 4 - Joint Filing Agreement dated April 15, 2005 by and between the Reporting Persons (incorporated by reference to Exhibit 1 to the Schedule 13Ds). EXHIBIT 5 - Power of Attorney dated April 15, 2005 by Chaumiere - - Consultadoria & Servicos SDC Unipessoal LDA (incorporated by reference to Exhibit 2 to the Schedule 13Ds). EXHIBIT 6 - Power of Attorney dated April 8, 2003 by and between the Reporting Persons (incorporated by reference to Exhibit 1 of Form 4, filed with the SEC on May 9, 2003, relating to the shares of Common Stock). 11

Signatures After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement with respect to Claudio Cavazza is true, complete and correct. Dated: December 15, 2006 CLAUDIO CAVAZZA By: /s/ MAURIZIO TERENZI ------------------------------ Maurizio Terenzi, Attorney-in-fact for Claudio Cavazza After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement with respect to Paolo Cavazza is true, complete and correct. Dated: December 15, 2006 PAOLO CAVAZZA By: /s/ MAURIZIO TERENZI ------------------------------ Maurizio Terenzi, Attorney-in-fact for Paolo Cavazza After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement with respect to Sigma-Tau Finanziaria SpA is true, complete and correct. Dated: December 15, 2006 SIGMA-TAU FINANZIARIA SPA By: /s/ MAURIZIO TERENZI ------------------------------ Maurizio Terenzi, Attorney-in-fact for Sigma-Tau Finanziari SpA After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement with respect to Sigma-Tau International S.A. is true, complete and correct. Dated: December 15, 2006 SIGMA-TAU INTERNATIONAL S.A. By: /s/ MAURIZIO TERENZI ------------------------------ Maurizio Terenzi, Attorney-in-fact for Sigma-Tau International S.A. 12

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement with respect to Defiante Farmaceutica L.D.A. is true, complete and correct. Dated: December 15, 2006 DEFIANTE FARMACEUTICA L.D.A. By: /s/ MAURIZIO TERENZI ------------------------------ Maurizio Terenzi, Attorney-in-fact for Defiante Farmaceutica L.D.A. After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement with respect to Aptafin S.p.A. is true, complete and correct. Dated: December 15, 2006 APTAFIN S.P.A. By: /s/ MAURIZIO TERENZI ------------------------------ Maurizio Terenzi, Attorney-in-fact for Aptafin S.p.A. After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement with respect to Chaumiere - Consultadoria & Servicos SDC Unipessoal LDA is true, complete and correct. Dated: December 15, 2006 CHAUMIERE - CONSULTADORIA & SERVICOS SDC UNIPESSOAL LDA By: /s/ MAURIZIO TERENZI ------------------------------ Maurizio Terenzi, Attorney-in-fact for Chaumiere - Consultadoria & Servicos SDC Unipessoal LDA The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative (other than an executive officer or general partner of the filing person), evidence of the representative's authority to sign on behalf of such person shall be filed with the statement: provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature. Attention: Intentional misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001) 13

Schedule A EXECUTIVE OFFICERS AND DIRECTORS Sigma Tau Finanziaria SpA NAME ADDRESS TITLE CITIZENSHIP ---- ------- ----- ----------- Claudio Cavazza via Pontina Km. 30,400, President Italian 00040 Pomezia (Rome) Italy Mario Artali via Sudafrica,20, Director Italian 00144 Rome Italy- Antonio Nicolai via Sudafrica,20, Managing Director Italian 00144 Rome Italy Vittorio Ripa di Meana piazza dei Caprettari, 70, Director Italian 00186 Rome Italy- Mauro Bove via Sudafrica,20, Director Italian 00144 Rome Italy Piero Belletti Viale Shakespeare 47 Director Italian 00144 Rome Italy Emilio Plate via Pontina Km. 30,400 Vice President Italian 00040 Pomezia (Rome) Italy Maurizio Terenzi via Sudafrica,20, Director Italian 00144 Rome Italy- Enrico Cavazza Via Pontina Km. 30,400 Director Italian 00040 Pomezia (Rome) Italy Marco Cerrina Feroni Piazza Paolo Ferrari 10 Director Italian 20121 Milano, Italy 14

Schedule A EXECUTIVE OFFICERS AND DIRECTORS Sigma-Tau International S.A. NAME ADDRESS TITLE CITIZENSHIP ---- ------- ----- ----------- Mario Artali via Sudafrica,20, President Italian 00144 Rome Italy Jean-Marc Leonard Bd. Du Prince Henri 19-21 Director French L-1724 Luxembourg Luca Checchinato Bd. Du Prince Henri 19-21 Director Italian L-1724 Luxembourg Antonio Nicolai via Sudafrica,20, Director Italian 00144 Rome Italy Mauro Bove via Sudafrica,20, Director Italian 00144Rome Italy Gustave Stoffel 18 Avenue De La Porte Neuve Director Luxembourg L-2227 Luxembourg Dominique Audia Bd. Du Prince Henri 19-21 Director French L-1724 Luxembourg 15

Schedule A EXECUTIVE OFFICERS AND DIRECTORS Defiante Farmaceutica L.D.A. NAME ADDRESS TITLE CITIZENSHIP ---- ------- ----- ----------- Antonio Nicolai via Sudafrica,20, Director Italian 00144 Rome Italy Raffaele Sanguigni Via Pontina Km. 30.400 - 00040 Pomezia Director Italian (Rome) Italy Paulo Alexandre da Mota Viegas Rua dos Tanoeiros, 12(0) - 2(0) e 3(0) - Funchal - Director Portuguese Madeira - Portugal 9000 Pedro Moreira da Cruz Quintas Rua dos Ferreiros, 260 - Funchal - Madeira - Director Portuguese Portugal 9000-082 Carla Emanuel Arruda Jardim Rua dos Ferreiros, 260 - Funchal - Madeira - Director Portuguese Fernandes Portugal 9000-082 16

Schedule A EXECUTIVE OFFICERS AND DIRECTORS Aptafin S.p.A. NAME ADDRESS TITLE CITIZENSHIP ---- ------- ----- ----------- Cristina Cavazza Viale Shakespeare, 47 President Italian 00144 Rome Italy Piero Belletti Viale Shakespeare, 47 Managing Director Italian 00144 Rome Italy Antonio Nicolai via Sudafrica,20, Director Italian 00144 Rome Italy- Emanuela Cavazza Viale Shakespeare 47 Director Italian 00144 Rome Italy- 17

Schedule A EXECUTIVE OFFICERS AND DIRECTORS Chaumiere - Consultadoria & Servicos SDC Unipessoal LDA NAME ADDRESS TITLE CITIZENSHIP ---- ------- ----- ----------- Roberto Carlos de Avenida da Republica, 32, 4.(Degree) Director Portuguese Castro Abreu Esquerdo, 1050-193 Lisboa, Portugal Joao Jose de Freitas Avenida da Republica, 32, 4.(Degree) Director Portuguese Rodrigues Esquerdo, 1050-193 Lisboa, Portugal